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Brand names: Dipyridamole, Persantine, Aggrenox
Mechanism of Action Dipyridamole inhibits the uptake of adenosine into platelets, endothelial cells and erythrocytes in vitro and in vivo ; the inhibition occurs in a dose-dependent manner at therapeutic concentrations (0.5 to 1.9 mcg/mL). This inhibition results in an increase in local concentrations of adenosine which acts on the platelet A 2 -receptor thereby stimulating platelet adenylate cyclase and increasing platelet cyclic-3',5'-adenosine monophosphate (cAMP) levels. Via this mechanism, platelet aggregation is inhibited in response to various stimuli such as platelet activating factor (PAF), collagen and adenosine diphosphate (ADP). Dipyridamole inhibits phosphodiesterase (PDE) in various tissues. While the inhibition of cAMP-PDE is weak, therapeutic levels of dipyridamole inhibit cyclic-3',5'-guanosine monophosphate-PDE (cGMP-PDE), thereby augmenting the increase in cGMP produced by EDRF (endothelium-derived relaxing factor, now identified as nitric oxide).
Contraindications
4 documented side effects by frequency
9 Reddit threads analysed for DIPYRIDAMOLE
Overall Sentiment
Slightly positive
Comparison Threads
0
Avg Post Score
16 upvotes
Most discussed side effects in community
I am not a doctor and this isn't medical advice. What follows below is solely from my personal experience over 9 years with severe restless legs. **tl;dr -** *Lifestyle changes are critical. No great options for severe RLS. YMMV but some alternative approaches do work (perhaps just for me), and they
Before I go any further, I should point out that this in no way constitutes medical advice, or an alternative to medically administered treatments. I just read a lot and have saved info as I find it and this shouldn't be taken as a suggestion to go out and buy any particular thing. The purpose of th
Before I go any further, I should point out that this in no way constitutes medical advice, or an alternative to medically administered treatments. I just read a lot and have saved info as I find it and this shouldn't be taken as a suggestion to go out and buy any particular thing. The purpose of th
I work as a family physician sub in Europe and am relatively new to the field. Graduated recently from med school and have only 2 months of work experience here. Regardless, had a patient today (45 y male) who's a bit new to this town, who has had a history of asthma, bipolar illness and stroke in
This is for people with Refractory RLS or "long term iron-insufficient" RLS (my made-up medical category). People who respond to iron supplementation. For those with genetic RLS, this might not be the right path. Two new studies came out [https://thejournalofheadacheandpain.biomedcentral.com/arti
Toe spacers help relieve my rls. I don't know how or why and I have no science to back it up but it definitely helps. I wear [these](https://www.amazon.co.uk/Separators-Strengthener-DYKOOK-Correcting-Overlapping/dp/B0BGNBLMWZ/ref=sr_1_3?keywords=toe+spacers&qid=1670073731&sr=8-3) when going
Patient was discharged on the following, and there are some major issues here. -rivaroxaban 20mg once daily -dipyridamole/aspirin (200/25) bd -celecoxib 200mg q8h prn -Dihydrochlorothiazide 25mg once daily in the morning -telmisartan 40mg once daily - lithium 250mg bd Forgot to add these oxycodone/
Hi all, I’ve been dealing with various LC symptoms for a little over a year now. Most of my symptoms have to do with my heart. I have the usual tachycardia, pvcs, chest tightness, periodic shortness of breath, dizziness, etc. After lots of pushing my cardiologist has finally ordered a cardiac mri to
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4 available comparisons
Dosage Forms
Tablet
Route
Oral