Medical Disclaimer: This site provides informational comparisons only and is not a substitute for professional medical advice, diagnosis, or treatment. Always consult your physician or pharmacist before making medication decisions.
Brand names: Tikosyn
Mechanism of Action Dofetilide shows Vaughan Williams Class III antiarrhythmic activity. The mechanism of action is blockade of the cardiac ion channel carrying the rapid component of the delayed rectifier potassium current, I Kr . At concentrations covering several orders of magnitude, dofetilide blocks only I Kr with no relevant block of the other repolarizing potassium currents (e.g., I Ks , I K1 ). At clinically relevant concentrations, dofetilide has no effect on sodium channels (associated with Class I effect), adrenergic alpha-receptors, or adrenergic beta-receptors.
Contraindications
9 documented side effects by frequency
8 Reddit threads analysed for DOFETILIDE
Overall Sentiment
Mixed
Comparison Threads
1
Avg Post Score
10 upvotes
Most discussed side effects in community
Threads directly comparing DOFETILIDE to other medications
In the context of a code/rrt when the patient has a prolonged qtc or is on dofetilide, sotalol, etc- if they need lidocaine or amiodarone, do you steer away from amiodarone and pick lidocaine? Assuming they are both available. Do you not even ever take the qtc/sotalol into account during a code? Per
Hi r/pharmacy community, I’m a hospital pharmacist tasked with the duty of establishing dofetilide initiation guidelines for my local hospital. Wanted to reach out to see if any other fellow hospital pharmacists can provide me with a copy of their guidelines that they follow at their hospital just s
Has anyone tried Dofetilide? I had my 4th ablation back in August and it didn’t work. I am definitely over ablations at this point as all 4 have had complications. My EP recommended Dofetilide, but I have to do a 3 day hospital stay when starting. Been through plenty of drugs and they either don’t w
EP is recommending Dofetilide, but I've read several medical reviews/journals thst say people with paroxmayl afib that self corrects in less than 24 hours, shouldn't take it. I am symptomatic when it happens, as in I can feel the second it starts and it does cause chest discomfort. I am that person
I was admitted to the hospital yesterday. Turns out I’m in AFIB yet again. My EP has started me on Dofetilide. Because I’m this is twice in three months. Does anyone have any experience with this medication.
I had ohs surgery fall 2019 for mitral valve replacement. As a result “complication” I’ve had aflutter and now afib. I’ve had to be converted a few times, but since July have not responded to medications to keep it in check. They would like to try Tikosyn/Dofetilide under three day observation. The
Bacterial infections affect nearly everyone at some point in their lifetime, and these conditions are commonly treated with broad spectrum antibiotics like azithromycin and erythromycin. Unfortunately, erythromycin in particular is associated with a number of uncomfortable side effects, including ga
Background: - Several years of Paroxysmal AFIB. Not limiting but concerned about "remodeling heart." - Ablation at 65 YO, went well. Fit guy with daily exercise. - Dofetilide (Tikosyn) for a year, all good but restrained HR to zone 1 - Came off Tikosyn and developed stable flutter. Exercise H
Community discussions are sourced from public Reddit threads. Content reflects individual opinions and is not medical advice.
6 available comparisons
Dosage Forms
Tablet
Route
Oral