DONEPEZIL HYDROCHLORIDE

Alzheimer's Agent

Brand names: DONEPEZIL HYDROCHLORIDE, Aricept

Oral

Mechanism of Action

12.1 Mechanism of Action Current theories on the pathogenesis of the cognitive signs and symptoms of Alzheimer's disease attribute some of them to a deficiency of cholinergic neurotransmission. Donepezil hydrochloride is postulated to exert its therapeutic effect by enhancing cholinergic function. This is accomplished by increasing the concentration of acetylcholine through reversible inhibition of its hydrolysis by acetylcholinesterase. There is no evidence that donepezil alters the course of the underlying dementing process.

Indications

moderate

and severe Alzheimer's Disease ( 1 ). Donepezil hydrochloride tablet is indicated for the treatment of dementia of the Alzheimer's type. Efficacy has been demonstrated in patients with mild

moderate

and severe Alzheimer's disease.

FDA Warnings

5 WARNINGS AND PRECAUTIONS Cholinesterase inhibitors are likely to exaggerate succinylcholine-type muscle relaxation during anesthesia ( 5
3 ) Patients should be monitored closely for symptoms of active or occult gastrointestinal (GI) bleeding, especially those at increased risk for developing ulcers ( 5
Therefore, patients should be monitored closely for symptoms of active or occult gastrointestinal bleeding, especially those at increased risk for developing ulcers, e

Known Side Effects

10 documented side effects by frequency

Falls

>10%

Dizziness

1-10%

Diarrhea

1-10%

Fatigue

1-10%

Nausea

1-10%

Drug Not Working

1-10%

Weakness

1-10%

Drowsiness

1-10%

Vomiting

1-10%

Decreased Appetite

0.1-1%

Community Discussions

1 Reddit threads analysed for DONEPEZIL HYDROCHLORIDE

Overall Sentiment

Mixed

Comparison Threads

Avg Post Score

780 upvotes

Patient Experiences (r/pharmacy, r/AskDocs & more)

Another Alzheimer's failure: A Phase 3 trial of the 5-HT6 antagonist, intepirdine, in over 1,300 people with mild to mod…

This morning Axovant Sciences [announced](http://investors.axovant.com/news-releases/news-release-details/axovant-announces-negative-topline-results-intepirdine-phase-3) that the Phase 3 clinical trial of its potential Alzheimer's drug, intepirdine, in patients with mild to moderate Alzheimer's dise

r/science780368y ago

Community discussions are sourced from public Reddit threads. Content reflects individual opinions and is not medical advice.

Compare With

8 available comparisons

Formulations

Dosage Forms

Tablet

Route

Oral