DOPAMINE HYDROCHLORIDE IN DEXTROSE

Electrolyte / Mineral

Brand names: Dopamine Hydrochloride in Dextrose

Intravenous

Mechanism of Action

12.1 Mechanism of Action Dopamine is a natural catecholamine formed by the decarboxylation of 3,4-dihydroxyphenylalanine (DOPA). It is a precursor to norepinephrine in noradrenergic nerves and is also a neurotransmitter in certain areas of the central nervous system, especially in the nigrostriatal tract, and in a few peripheral sympathetic nerves. Dopamine elicits its pharmacological action by activating dopamine D1 and D2 receptors, beta-1 receptors and alpha-1 receptors. The activation of different receptors leading to its effects are dependent on dopamine dose.

Indications

1 INDICATIONS AND USAGE Dopamine Hydrochloride in Dextrose Injection is indicated to improve hemodynamic status in patients in distributive shock

or shock due to reduced cardiac output. Dopamine HCl in Dextrose Injection is a catecholamine indicated to improve hemodynamic status in patients in shock. ( 1 )

Contraindications

• 4 CONTRAINDICATIONS Dopamine is contraindicated in patients with pheochromocytoma. Patients with pheochromocytoma. ( 4 )

FDA Warnings

5 WARNINGS AND PRECAUTIONS • Tissue ischemia : Severe peripheral and visceral vasoconstriction can occur
To reduce the risk of extravasation, infuse into a large vein [see Dosage and Administration (2

Known Side Effects

6 documented side effects by frequency

Drug Not Working

>10%

Low Blood Pressure

>10%

Condition Worsened

1-10%

Fever

0.1-1%

Shortness of Breath

0.1-1%

Diarrhea

0.1-1%

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Formulations

Dosage Forms

Tablet

Route

Intravenous