DORZOLAMIDE HYDROCHLORIDE AND TIMOLOL MALEATE OPHTHALMIC SOLUTION

Glaucoma Agent

Brand names: Dorzolamide Hydrochloride and Timolol Maleate Ophthalmic Solution

Ophthalmic

Mechanism of Action

12.1 Mechanism of Action Dorzolamide hydrochloride and timolol maleate ophthalmic solution is comprised of two components: dorzolamide hydrochloride and timolol maleate. Each of these two components decreases elevated intraocular pressure, whether or not associated with glaucoma, by reducing aqueous humor secretion. Elevated intraocular pressure is a major risk factor in the pathogenesis of optic nerve damage and glaucomatous visual field loss. The higher the level of intraocular pressure, the greater the likelihood of glaucomatous field loss and optic nerve damage. Dorzolamide hydrochloride is an inhibitor of human carbonic anhydrase II. Inhibition of carbonic anhydrase in the ciliary processes of the eye decreases aqueous humor secretion, presumably by slowing the formation of bicarbonate ions with subsequent reduction in sodium and fluid transport. Timolol maleate is a beta1 and beta2 (non-selective) adrenergic receptor blocking agent that does not have significant intrinsic sympath

Indications

and 2% dorzolamide three times daily. ( 1 )

Contraindications

• 4 CONTRAINDICATIONS Dorzolamide hydrochloride and timolol maleate ophthalmic solution is contraindicated in patients with: Bronchial asthma or a history of bronchial asthma
• severe chronic obstructive pulmonary disease.( 4.1 ) Sinus bradycardia
• second or third degree atrioventricular block
• overt cardiac failure
• cardiogenic shock. ( 4.2 ) Hypersensitivity to any component of this product. ( 4.3

FDA Warnings

5 WARNINGS AND PRECAUTIONS Potentiation of Respiratory Reactions Including Asthma ( 5
For example, severe respiratory reactions, including death due to bronchospasm in patients with asthma, and rarely death in association with cardiac failure, have been reported following systemic or ophthalmic administration of timolol maleate [see Contraindications ( 4
Fatalities have occurred, although rarely, due to severe reactions to sulfonamides including Stevens-Johnson syndrome, toxic epidermal necrolysis, fulminant hepatic necrosis, agranulocytosis, aplastic anemia, and other blood dyscrasias
If signs of serious reactions or hypersensitivity occur, discontinue the use of this preparation [see Contraindications ( 4

Known Side Effects

5 documented side effects by frequency

Drug Not Working

>10%

Fatigue

1-10%

Headache

0.1-1%

Blurred Vision

0.1-1%

Shortness of Breath

0.1-1%

Community Discussions

1 Reddit threads analysed for DORZOLAMIDE HYDROCHLORIDE AND TIMOLOL MALEATE OPHTHALMIC SOLUTION

Overall Sentiment

Slightly positive

Comparison Threads

Avg Post Score

244 upvotes

Most discussed side effects in community

Vision Changes (1)

Patient Experiences (r/pharmacy, r/AskDocs & more)

There is a cure for Glaucoma and it is being suppressed.

I know this story will sound unbelievable and too good to be true but I ask that you please keep an open mind. My OD started me out on generic latanoprost, and that worked to lower my pressures below 20 (for a while). After some time my pressures started creeping back up, and she put me on a beta bl

r/conspiracy244495y ago

Vision Changes

Community discussions are sourced from public Reddit threads. Content reflects individual opinions and is not medical advice.

Compare With

15 available comparisons

Formulations

Dosage Forms

Tablet

Route

Ophthalmic