DORZOLAMIDE HYDROCHLORIDE AND TIMOLOL MALEATE

Glaucoma Agent

Brand names: Dorzolamide Hydrochloride and Timolol Maleate ophthalmic Solution

Ophthalmic

Mechanism of Action

12.1 Mechanism of Action Dorzolamide hydrochloride and timolol maleate ophthalmic solution is comprised of two components: dorzolamide hydrochloride and timolol maleate. Each of these two components decreases elevated intraocular pressure, whether or not associated with glaucoma, by reducing aqueous humor secretion. Elevated intraocular pressure is a major risk factor in the pathogenesis of optic nerve damage and glaucomatous visual field loss. The higher the level of intraocular pressure, the greater the likelihood of glaucomatous field loss and optic nerve damage. Dorzolamide hydrochloride is an inhibitor of human carbonic anhydrase II. Inhibition of carbonic anhydrase in the ciliary processes of the eye decreases aqueous humor secretion, presumably by slowing the formation of bicarbonate ions with subsequent reduction in sodium and fluid transport. Timolol maleate is a beta 1 and beta 2 (non-selective) adrenergic receptor blocking agent that does not have significant intrinsic sympa

Indications

a carbonic anhydrase inhibitor

and timolol maleate

a beta adrenergic receptor blocking agent

and 2% dorzolamide three times daily. ( 1 )

Contraindications

• 4 CONTRAINDICATIONS Dorzolamide hydrochloride and timolol maleate ophthalmic solution is contraindicated in patients with: Bronchial asthma or a history of bronchial asthma
• severe chronic obstructive pulmonary disease.( 4.1 ) Sinus bradycardia
• second or third degree atrioventricular block
• overt cardiac failure
• cardiogenic shock. ( 4.2 ) Hypersensitivity to any component of this product. ( 4.3

FDA Warnings

5 WARNINGS AND PRECAUTIONS Potentiation of Respiratory Reactions Including Asthma ( 5
For example, severe respiratory reactions, including death due to bronchospasm in patients with asthma, and rarely death in association with cardiac failure, have been reported following systemic or ophthalmic administration of timolol maleate [see Contraindications (4
Fatalities have occurred, although rarely, due to severe reactions to sulfonamides including Stevens-Johnson syndrome, toxic epidermal necrolysis, fulminant hepatic necrosis, agranulocytosis, aplastic anemia, and other blood dyscrasias
If signs of serious reactions or hypersensitivity occur, discontinue the use of this preparation [see Contraindications (4

Known Side Effects

5 documented side effects by frequency

Drug Not Working

>10%

Fatigue

1-10%

Headache

0.1-1%

Blurred Vision

0.1-1%

Shortness of Breath

0.1-1%

Community Discussions

3 Reddit threads analysed for DORZOLAMIDE HYDROCHLORIDE AND TIMOLOL MALEATE

Overall Sentiment

Mixed

Comparison Threads

Avg Post Score

1,827 upvotes

Most discussed side effects in community

Itching (1)

Patient Experiences (r/pharmacy, r/AskDocs & more)

i think i just discovered why my eyedrops burned so bad last night

r/mildlyinfuriating5,1941232y ago

How tf am I supposed to work in this med room

The floor is so sticky 🤮🤢 Do not get me started on the state of the residents here if you think the med room is bad. Stuck between needing a job and wanting to help the people here, and wanting to dip the fuck out and protect my certification. but one enthusiastic med aide over the weekends isn’t

r/cna2835111mo ago

Eye lid irritation from drops

My mother has pseudoexfoliation open angle glaucoma and complains to me all the time about how her eye drops cause the skin around her eyes and eyelids to itch. She mentioned trying to use Vaseline to protect them but that did not help. She also mentioned that putting any kind of makeup or cream mak

r/Glaucoma352y ago

Itching

Community discussions are sourced from public Reddit threads. Content reflects individual opinions and is not medical advice.

Compare With

15 available comparisons

Formulations

Dosage Forms

Tablet

Route

Ophthalmic