DOXEPIN HYDROCHLORIDE

Tricyclic Antidepressant

Brand names: Doxepin hydrochloride

Oral

Mechanism of Action

12.1 Mechanism of Action The mechanism of action of doxepin in sleep maintenance is unclear; however, doxepin’s effect could be mediated through antagonism of the H1 receptor.

Indications

14 )

Contraindications

• 4 CONTRAINDICATIONS Hypersensitivity to doxepin hydrochloride
• inactive ingredients
• any of its inactive ingredients

FDA Warnings

5 WARNINGS AND PRECAUTIONS Need to Evaluate for Co-morbid Diagnoses: Reevaluate if insomnia persists after 7 to 10 days of use
Although behaviors such as “sleep-driving” may occur with hypnotics alone at therapeutic doses, the use of alcohol and other CNS depressants with hypnotics appears to increase the risk of such behaviors, as does the use of hypnotics at doses exceeding the maximum recommended dose
Due to the risk to the patient and the community, discontinuation of doxepin should be strongly considered for patients who report a “sleep-driving” episode
3 Suicide Risk and Worsening of Depression In primarily depressed patients, worsening of depression, including suicidal thoughts and actions (including completed suicides), has been reported in association with the use of hypnotics

Known Side Effects

11 documented side effects by frequency

Drug Not Working

1-10%

Fatigue

1-10%

Nausea

1-10%

Headache

1-10%

Insomnia

1-10%

Dizziness

1-10%

Itching

1-10%

Anxiety

1-10%

Falls

1-10%

Diarrhea

1-10%

Shortness of Breath

1-10%

Community Discussions

No community discussions found for DOXEPIN HYDROCHLORIDE yet.

Compare With

12 available comparisons

Formulations

Dosage Forms

Tablet

Route

Oral