ESCITSLOPRAM

Other

Brand names: Escitalopram

Oral

Mechanism of Action

12.1 Mechanism of Action The mechanism of antidepressant action of escitalopram, the S-enantiomer of racemic citalopram, is presumed to be linked to potentiation of serotonergic activity in the central nervous system (CNS) resulting from its inhibition of CNS neuronal reuptake of serotonin (5-HT).

Indications

due to AbbVie Inc.'s marketing exclusivity rights

FDA Warnings

5 WARNINGS AND PRECAUTIONS Serotonin Syndrome: Increased risk when co-administered with other serotonergic agents but also when taken alone
6 ) Increased Risk of Bleeding: Concomitant use of nonsteroidal anti-inflammatory drugs, aspirin, other antiplatelet drugs, warfarin and other drugs that affect coagulation may increase risk ( 5
There was considerable variation in risk of suicidal thoughts and behaviors among drugs, but there was an increased risk identified in young patients for most drugs studied
There were differences in absolute risk of suicidal thoughts and behaviors across the different indications, with the highest incidence in patients with MDD

Known Side Effects

13 documented side effects by frequency

Drug Not Working

1-10%

Fatigue

1-10%

Nausea

1-10%

Diarrhea

1-10%

Headache

1-10%

Falls

1-10%

Anxiety

1-10%

Dizziness

1-10%

Depression

1-10%

Vomiting

1-10%

Condition Worsened

1-10%

Shortness of Breath

1-10%

Drowsiness

1-10%

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Formulations

Dosage Forms

Tablet

Route

Oral