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12.1 Mechanism of Action Endogenous estrogens are largely responsible for the development and maintenance of the female reproductive system and secondary sexual characteristics. Although circulating estrogens exist in a dynamic equilibrium of metabolic interconversions, estradiol is the principal intracellular human estrogen and is substantially more potent than its metabolites, estrone and estriol, at the receptor level. The primary source of estrogen in normally cycling adult women is the ovarian follicle, which secretes 70 to 500 mcg of estradiol daily, depending on the phase of the menstrual cycle. After menopause, most endogenous estrogen is produced by conversion of androstenedione, which is secreted by the adrenal cortex, to estrone in the peripheral tissues. Thus, estrone and the sulfate conjugated form, estrone sulfate, are the most abundant circulating estrogens in postmenopausal women. Estrogens act through binding to nuclear receptors in estrogen-responsive tissues. To date
Contraindications
8 documented side effects by frequency
8 Reddit threads analysed for ESTRADIOL AND LEVONORGESTREL
Overall Sentiment
Slightly positive
Comparison Threads
0
Avg Post Score
55 upvotes
Most discussed side effects in community
Long time lurker here and first time ever reddit poster and decided I finally needed to break my silence to share with you something I learned in pharmacy school. A lot of people (myself included) have experienced terrible acne while on birth control even though its supposed to help. The truth is t
There are lots of IUD stories floating around, ranging from horrible to blissful. I thought I would share my experience and answer questions as best I can. I will answer any and all questions posted here, and feel free to PM me if you're more comfortable asking there. This is pretty long, so skip ar
This is meant to be a basic introduction to treatment recommendations. I've created it because I have been so frustrated with the lack of knowledge/education for patients and providers on the subject. I'd like to even the playing field, so women can go to their appointments with a basic understandin
Article by Dr. Jen Gunter I found very helpful from vajenda.substack.com Spotlight on Primary Ovarian Insufficiency There is a lot of terminology here, so let’s review it so we are all on the same page. Menopause occurs when ovulation stops, and this is expected to occur at age 45 or older. The aver
hi all! i [22F] just had a Kyleena inserted this afternoon and thought i would share my positive experience. i’ll try and update in the next month and so on! the tl;dr is that it was not as bad as i expected it to be. the most pain i felt was a 7/10 when she measured my uterus and inserted something
Below is my experience as follows taking Aviane 28. It’s a combined hormonal pill so it works by preventing ovulation, and I took it for 4 years starting in September 2017 and ending in September 2021. I originally started taking it at the suggestion of my mom when I was in my first serious relatio
I wish I had read a story like mine when I was first diagnosed, because I felt so completely alone in my experience. I'm sharing it so that others might relate and share their own. Thanks. I am BMI 18, lean PCOS. Have never weighed more than 120 pounds, currently at 115. Height 5'7". I got my per
The active ingredient in Plan B One Step is levonorgestrel 1.5mg. If someone took 10 tablets of the OC Levora (levonorgestrel and ethinyl estradiol tablets) 0.15mg/0.03mg), could that theoretically also work even though you’d also be getting the estrogen component too?
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Dosage Forms
Tablet
Route
Transdermal