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12.1 Mechanism of Action Endogenous estrogens are largely responsible for the development and maintenance of the female reproductive system and secondary sexual characteristics. Although circulating estrogens exist in a dynamic equilibrium of metabolic interconversions, estradiol is the principal intracellular human estrogen and is substantially more potent than its metabolites, estrone and estriol, at the receptor level. The primary source of estrogen in normally cycling adult women is the ovarian follicle, which secretes 70 to 500 mcg of estradiol daily, depending on the phase of the menstrual cycle. After menopause, most endogenous estrogen is produced by conversion of androstenedione, secreted by the adrenal cortex, to estrone in the peripheral tissues. Thus, estrone and the sulfate conjugated form, estrone sulfate, are the most abundant circulating estrogens in postmenopausal women. Estrogens act through binding to nuclear receptors in estrogen-responsive tissues. To date, two est
Contraindications
8 documented side effects by frequency
7 Reddit threads analysed for ESTRADIOL AND PROGESTERONE
Overall Sentiment
Slightly positive
Comparison Threads
0
Avg Post Score
515 upvotes
Most discussed side effects in community
I wanted to share my experience seeing an in-person menopause specialist—one recommended by The Menopause Society—because I thought I was on the right path. Unfortunately, it was frustrating and disappointing. I am a 43 year-old female, married, child free by choice, low stress job. I went to The
Just got on hrt last Friday, and the estradiol gel was not available until today Went to pick it up, and the pharmacist really questioned me about it. Asked if I am getting prescriptions at other pharmacies, made me feel like I was drug seeking? I said yes, I already got the testosterone at a compou
**Latest update: 2022-23-08** Hi all! It's the greenhorn Zoey again back with another question about all the confusing parts about being trans again! Me being me, I haven't yet had the courage to step out and post in the bigger trans subs. So for now I'm sticking close to my little secret space surr
I live in Ohio and today is the first day for recreational. I had been vacillating about getting a medical card but didn't know if I would be eligible. and the cost. etc.. but we finally got recreational and I am looking at some of these Gummies they have and they have descriptions of "energizing"
To preface this post, before I started transitioning nearly 2 years ago, I genuinely appreciated the posts from people who were further along in their transition than I was who shared their wisdom about the lessons they'd learned during their own journey. I've had this post more or less saved in my
I've been in perimenopause for probably 5-7 years, but with no noticeable symptoms besides wonky periods. Until recently. Migraines, hot flashes, mood swings, can't sleep, everything is dry and I'm constantly exhausted. I've been on a mission to try everything in my power to manage these symptoms, s
Hi pharmacy peeps! I'm a specialty pharmacist and have been for years, so I wanted to double-check this. Today, I was covering for a colleague and received a new prescription for cyproterone 12.5 mg daily for a patient who is transitioning. She is currently taking Prometrium (micronized progesterone
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15 available comparisons
Dosage Forms
Tablet
Route
Oral