ETHIODIZED OIL

Diagnostic Agent

Brand names: LIPIODOL

Intra-arterial, Intralymphatic, Intrauterine

Mechanism of Action

12.1 Mechanism of Action Lipiodol opacifies vessels and body structures in the path of the flow of the contrast medium, permitting visualization of the internal structures.

Indications

See full prescribing information

Contraindications

• 4 CONTRAINDICATIONS Lipiodol is contraindicated in patients with hypersensitivity to Lipiodol
• hyperthyroidism
• traumatic injuries
• recent hemorrhage or bleeding. Hysterosalpingography Lipiodol hysterosalpingography is contraindicated in pregnancy
• acute pelvic inflammatory disease

FDA Warnings

5 WARNINGS AND PRECAUTIONS Pulmonary and cerebral embolism: avoid use in patients with severely impaired lung function, cardiorespiratory failure or right-sided cardiac overload ( 5
1 ) Hypersensitivity reactions: avoid use in patients with a history of sensitivity to other iodinated contrast agents, bronchial asthma or allergic disorders because of an increased risk of a hypersensitivity reaction to Lipiodol ( 5
1 Pulmonary and Cerebral Embolism Pulmonary embolism may occur immediately or after a few hours to days from inadvertent systemic vascular injection or intravasation of Lipiodol and cause decreased pulmonary diffusing capacity and pulmonary blood flow, pulmonary infarction, acute respiratory distress syndrome and fatalities
During lymphography to minimize the risk of pulmonary embolism obtain radiographic confirmation of intralymphatic (rather than venous) injection, and terminate the procedure when Lipiodol becomes visible in the thoracic duct or lymphatic obstruction is observed

Known Side Effects

2 documented side effects by frequency

Fever

1-10%

Abdominal Pain

0.1-1%

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Formulations

Dosage Forms

Tablet

Route

Intra-arterial, Intralymphatic, Intrauterine