ETONOGESTREL

Progestin Contraceptive

Brand names: Nexplanon

Subcutaneous

Mechanism of Action

12.1 Mechanism of Action The contraceptive effect of NEXPLANON is achieved by suppression of ovulation, increased viscosity of the cervical mucus, and alterations in the endometrium.

Indications

See full prescribing information

Contraindications

• 4 CONTRAINDICATIONS NEXPLANON should not be used in women who have Known or suspected pregnancy Current or past history of thrombosis or thromboembolic disorders Liver tumors
• benign or malignant
• or active liver disease Undiagnosed abnormal uterine bleeding Known or suspected breast cancer
• personal history of breast cancer
• or other progestin-sensitive cancer

FDA Warnings

5 WARNINGS AND PRECAUTIONS The following information is based on experience with the etonogestrel implants (IMPLANON and/or NEXPLANON), other progestin-only contraceptives, or experience with combination (estrogen plus progestin) oral contraceptives
1 Risk of Complications Due to Improper Insertion and Removal Complications of Insertion and Removal NEXPLANON should be inserted subdermally so that it will be palpable after insertion, and this should be confirmed by palpation immediately after insertion
To help reduce the risk of neural or vascular injury, NEXPLANON should be inserted subdermally just under the skin at the inner side of the non-dominant upper arm overlying the triceps muscle, about 8-10 cm (3-4 inches) from the medial epicondyle of the humerus, and 3-5 cm (1
NEXPLANON is available only through a restricted program under a REMS [see Warnings and Precautions (5

Known Side Effects

0 documented side effects by frequency

No structured side effect data available.

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Compare With

1 available comparisons

vs LEVONORGESTREL

Formulations

Dosage Forms

Tablet

Route

Subcutaneous