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Brand names: Byetta, Bydureon
12.1 Mechanism of Action Incretins, such as glucagon-like peptide-1 (GLP-1), enhance glucose-dependent insulin secretion and exhibit other antihyperglycemic actions following their release into the circulation from the gut. BYETTA is a GLP-1 receptor agonist that enhances glucose-dependent insulin secretion by the pancreatic beta-cell, suppresses inappropriately elevated glucagon secretion, and slows gastric emptying. The amino acid sequence of exenatide partially overlaps that of human GLP-1. Exenatide has been shown to bind and activate the human GLP-1 receptor in vitro . This leads to an increase in both glucose-dependent synthesis of insulin, and in vivo secretion of insulin from pancreatic beta cells, by mechanisms involving cyclic AMP and/or other intracellular signaling pathways. BYETTA improves glycemic control by reducing fasting and postprandial glucose concentrations in patients with type 2 diabetes through the actions described below.
Contraindications
10 documented side effects by frequency
9 Reddit threads analysed for EXENATIDE
Overall Sentiment
Mixed
Comparison Threads
0
Avg Post Score
65 upvotes
Most discussed side effects in community
60yr SW 95kg GW 70kg After 5 months I’ve achieved my goal weight. I’ve not been this weight since a teenager. Tried every diet over the years but only had temporary success. Always struggled with food noise. Retired early as a GP in the UK due to MH in 2022. Turned 60 earlier this year & finall
I'm just curious. The more I experience this pain and weakness the more I realize this is what sleep deprivation is. Without proper restorative sleep you get the exact same symptoms. Poorer sleep leads to a disruption in hormonal levels which makes sense why this affects more women then men. They
I just finished reading an *excellent* series of blog posts about how the fear of insulin is mostly bullshit. I wanted to understand the articles better, and contribute to fittit, so I went through each article and summarized them the best as I could in layman terms. All of them are worth a read, an
Since we can't submit links on this sub, I'm pasting an interesting article I saw today. It's by Sarah Zhang for the Atlantic. Did Scientists Accidentally Invent an Anti-addiction Drug? People taking Ozempic for weight loss say they have also stopped drinking, smoking, shopping, and even nail biting
Fair warning: this will be a long post filled with data and graphs and some potentially controversial commentary. You may feel the urge to express how I am doing something wrong, not eating enough, etc. I’ve seen and read it all so it will fall on deaf ears here, but have at it I suppose. I plan to
My health plan formulary updates for GLPS! As a PA tech, not looking forward to alllllll the calls and PAs we’re about to get lol -GLP medications for diabetes will require step-therapy on October 1 2023. This update applies to dulaglutide (Trulicity), exenatide (Bydureon and Byetta), liraglutide (
Invex Therapeutics # Background Invex Therapeutics is a clinical stage biopharmaceutical company incorporated on the 8th of March in 2019 which is repurposing an orphan drug (Exenatide) for initial use in the indication of Idiopathic Intracranial Hypertension (IIH). A basic understanding of the sc
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22 available comparisons
Dosage Forms
Tablet
Route
Subcutaneous