FERUMOXYTOL

Other

Brand names: Feraheme

Intravenous

Mechanism of Action

12.1 Mechanism of Action Feraheme consists of a superparamagnetic iron oxide that is coated with a carbohydrate shell, which helps to isolate the bioactive iron from plasma components until the iron-carbohydrate complex enters the reticuloendothelial system macrophages of the liver, spleen and bone marrow. The iron is released from the iron-carbohydrate complex within vesicles in the macrophages. Iron then either enters the intracellular storage iron pool (e.g., ferritin) or is transferred to plasma transferrin for transport to erythroid precursor cells for incorporation into hemoglobin.

Indications

See full prescribing information

FDA Warnings

5 WARNINGS AND PRECAUTIONS • Greater risk of anaphylaxis in patients with multiple drug allergies
1 Serious Hypersensitivity Reactions Fatal and serious hypersensitivity reactions including anaphylaxis, presenting with cardiac/ cardiorespiratory arrest, clinically significant hypotension, syncope, or unresponsiveness have occurred in patients receiving Feraheme
Patients with a history of multiple drug allergies may have a greater risk of anaphylaxis with parenteral iron products
Carefully consider the potential risks and benefits before administering Feraheme to these patients

Known Side Effects

9 documented side effects by frequency

Shortness of Breath

>10%

Nausea

1-10%

Back Pain

1-10%

Low Blood Pressure

1-10%

Dizziness

1-10%

Chest Pain

0.1-1%

Vomiting

0.1-1%

Excessive Sweating

0.1-1%

Itching

0.1-1%

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Formulations

Dosage Forms

Tablet

Route

Intravenous