How does FLUMAZENIL work?

FLUMAZENIL works through the following mechanism: Benzodiazepine agent.

What are the most common side effects of FLUMAZENIL?

Reported side effects vary by individual. The side-effects section on this page lists the events most frequently reported to FDA FAERS for FLUMAZENIL. FAERS is voluntary reporting, so it reflects what was reported, not absolute incidence.

Is FLUMAZENIL the same as FLUMAZENIL?

FLUMAZENIL is a brand name for FLUMAZENIL. They share the same active ingredient and FDA-approved indications. Biosimilars and authorised generics may differ in inactive ingredients such as buffers or preservatives.

FLUMAZENIL

Q: What is FLUMAZENIL used for?

FLUMAZENIL (brand name FLUMAZENIL) is a Benzodiazepine indicated for INDICATIONS AND USAGE Adult Patients Flumazenil Injection, USP is indicated for the complete or partial reversal of the sedative effects of benzodiazepines in cases where general anesthesia has been induced and/or maintained with benzodiazepines, where sedation has been produced with benzodiazepines for diagnostic and therapeutic procedures.

Benzodiazepine

Brand names: FLUMAZENIL

Intravenous

Mechanism of Action

Benzodiazepine agent

Indications

INDICATIONS AND USAGE Adult Patients Flumazenil Injection

USP is indicated for the complete or partial reversal of the sedative effects of benzodiazepines in cases where general anesthesia has been induced and/or maintained with benzodiazepines

where sedation has been produced with benzodiazepines for diagnostic and therapeutic procedures

and for the management of benzodiazepine overdose. Pediatric Patients (aged 1 to 17) Flumazenil Injection

USP is indicated for the reversal of conscious sedation induced with benzodiazepines (see PRECAUTIONS: Pediatric Use ).

Contraindications

• control of intracranial pressure or status epilepticus). in patients who are showing signs of serious cyclic antidepressant overdose (see WARNINGS ).

FDA Warnings

WARNINGS Risk of Seizures The reversal of benzodiazepine effects may be associated with the onset of seizures in certain high-risk populations
Possible risk factors for seizures include: concurrent major sedative-hypnotic drug withdrawal, recent therapy with repeated doses of parenteral benzodiazepines, myoclonic jerking or seizure activity prior to flumazenil administration in overdose cases, or concurrent cyclic antidepressant poisoning
Flumazenil is not recommended in cases of serious cyclic antidepressant poisoning, as manifested by motor abnormalities (twitching, rigidity, focal seizure), dysrhythmia (wide QRS, ventricular dysrhythmia, heart block), anticholinergic signs (mydriasis, dry mucosa, hypoperistalsis), and cardiovascular collapse at presentation
Treatment with flumazenil has no known benefit to the seriously ill mixed-overdose patient other than reversing sedation and should not be used in cases where seizures (from any cause) are likely

Known Side Effects

3 documented side effects by frequency

Drug Not Working

1-10%

Low Blood Pressure

1-10%

Drowsiness

0.1-1%

Community Discussions

8 Reddit threads analysed for FLUMAZENIL

Overall Sentiment

Slightly negative

Comparison Threads

Avg Post Score

453 upvotes

Most discussed side effects in community

Rash (2)

Vision Changes (2)

Anxiety (2)

Fatigue (1)

Headache (1)

Drowsiness (1)

Patient Experiences (r/pharmacy, r/AskDocs & more)

My patient spent eight million years under a bench at the Glenmont metro [Part 1]

\[[Part 0](https://www.reddit.com/r/nosleep/comments/cokl1l/if_youre_armed_and_at_the_glenmont_metro_please/)\] No person - actually, no living thing - has experienced more suffering than clinical trial subject S-47. S-47 was a healthy male who volunteered to be a test subject for a trial of a drug

r/nosleep1,510873y ago

Rash

[ Removed by Reddit ]

[ Removed by Reddit on account of violating the [content policy](/help/contentpolicy). ]

r/nosleep1,004623y ago

My patient spent eight million years under a bench at the Glenmont metro [Part 2]

\[[Part 1](https://www.reddit.com/r/nosleep/comments/13ot7m0/my_patient_spent_eight_million_years_under_a/)\] I was suspended in midair. Helen’s lunge into me knocked me into the air - both my feet had left the floor. I could see Helen’s ankles and left hand at the edge of my vision. The syringe was

r/nosleep842403y ago

Fatigue

Vision Changes

pylori's Physiology Bites - Reduced consciousness, intracranial events, and the central nervous system

Welcome! This is a series I am going to be working on where I endeavour to cover various topics in physiology intermixed with clinical pearls to impart some knowledge that doctors of most specialties and grades will hopefully find useful when looking after acutely unwell patients. Join me as we dred

r/JuniorDoctorsUK195304y ago

Headache

Rash

Drowsiness

For 2nd Time NCLEX Test Takers

Hello everyone! I've been a long-time lurker on this sub, and I found out I passed the NCLEX today! When I failed the first time, I was depressed for weeks and found it hard to pick up the motivation to study again for the exam. Looking back, I was so disappointed in myself for not passing, and I ne

r/NCLEX2772y ago

House of Matriarch - *she* - New Fragrance Release Review! (Unisex Fragrance Review)

Here's my review of the brand new fragrance release from House of Matriarch called *she*. The review contains lots of cool photos and links here: http://enchantefragrance.com/she-house-matriarch-review/ _________________ She is a woody floral fragrance from House of Matriarch, created by Christi Me

r/fragrance21258y ago

Anxiety

Why doesn't naloxone/naltrexone block endorphins?

**In other words:** Why don't opiate free people experience some sort of withdrawal-like symptoms (or dysregulation syndrome) from opioid antagonists like naltrexone? Background: Neuro and pharmacology student. Recently I found out a friend of my is taking Vivotrol (naltrexone). I was a bit shocked

r/askscience1379y ago

Anxiety

How my Psych Rotation turned me into a Psych Patient…

So I surprisingly scored a 114 on the Psych COMAT which I’m happy about cause my studying methods are improving for rotations. I believe this would usually be considered a high pass for my school BUT… my preceptor was absolutely atrocious. He only talked 10% of psych and 90% bs politics/history/his

r/comlex942y ago

Community discussions are sourced from public Reddit threads. Content reflects individual opinions and is not medical advice.

Primary sources

Every figure on this page links back to its primary source. See data sources for full provenance.

DailyMed FDA label search → FLUMAZENIL openFDA label JSON → FLUMAZENIL FAERS adverse-event reports → FLUMAZENIL ClinicalTrials.gov → completed Phase 2+ trials of FLUMAZENIL

Compare With

14 available comparisons

Formulations

Dosage Forms

Tablet

Route

Intravenous