FLUORESCEIN SODIUM AND BENOXINATE HYDROCHLORIDE

Electrolyte / Mineral

Brand names: Fluorescein Sodium and Benoxinate Hydrochloride

Ophthalmic

Mechanism of Action

12.2 Pharmacodynamics Maximal corneal anesthesia usually occurs in about 5-45 seconds and lasts about 20 minutes after single administration. The anesthetic effect may be extended by subsequent administration 10-20 minutes after the last administration.

Indications

1 INDICATIONS AND USAGE Fluorescein Sodium and Benoxinate Hydrochloride Ophthalmic Solution

0.3%/0.4% is a combination of fluorescein sodium

a disclosing agent and benoxinate hydrochloride

a local ester anesthetic indicated for procedures in adult and pediatric patients requiring a disclosing agent in combination with a topical ophthalmic anesthetic. ( 1 )

Contraindications

• 4 CONTRAINDICATIONS Fluorescein Sodium and Benoxinate Hydrochloride Ophthalmic Solution
• 0.3%/0.4% is contraindicated in patients with known hypersensitivity to any component of this product. Known hypersensitivity to any component of this product. ( 4 )

FDA Warnings

5 WARNINGS AND PRECAUTIONS Corneal Toxicity : Prolonged use or abuse may lead to corneal epithelial toxicity and manifest as epithelial defects which may progress to permanent corneal damage

Known Side Effects

7 documented side effects by frequency

Nausea

>10%

Itching

>10%

Rash

1-10%

Dizziness

1-10%

Vomiting

1-10%

Shortness of Breath

1-10%

Excessive Sweating

0.1-1%

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Formulations

Dosage Forms

Tablet

Route

Ophthalmic