FOSINOPIRL SODIUM

Electrolyte / Mineral

Brand names: Fosinopril sodium

Oral

Mechanism of Action

Mechanism of Action In animals and humans, fosinopril sodium is hydrolyzed by esterases to the pharmacologically active form, fosinoprilat, a specific competitive inhibitor of angiotensin-converting enzyme (ACE). ACE is a peptidyl dipeptidase that catalyzes the conversion of angiotensin I to the vasoconstrictor substance, angiotensin II. Angiotensin II also stimulates aldosterone secretion by the adrenal cortex. Inhibition of ACE results in decreased plasma angiotensin II, which leads to decreased vasopressor activity and to decreased aldosterone secretion. The latter decrease may result in a small increase of serum potassium. In 647 hypertensive patients treated with fosinopril alone for an average of 29 weeks, mean increases in serum potassium of 0.1 mEq/L were observed. Similar increases were observed among all patients treated with fosinopril, including those receiving concomitant diuretic therapy. Removal of angiotensin II negative feedback on renin secretion leads to increased pl

Indications

consideration should be given to the fact that another angiotensin-converting enzyme inhibitor

captopril

has caused agranulocytosis

it should be noted that in controlled trials ACE inhibitors have an effect on blood pressure that is less in black patients than in non-blacks. In addition

ACE inhibitors (for which adequate data are available) cause a higher rate of angioedema in black than in non-black patients (see WARNINGS

Head and Neck Angioedema and Intestinal Angioedema ).

Contraindications

• CONTRAINDICATIONS Fosinopril sodium tablets are contraindicated in patients who are hypersensitive to this product or to any other angiotensin-converting enzyme inhibitor (e.g.
• a patient who has experienced angioedema with any other ACE inhibitor therapy). Do not co-administer fosinopril sodium tablets with aliskiren in patients with diabetes.

FDA Warnings

WARNING: FETAL TOXICITY • When pregnancy is detected, discontinue fosinopril sodium tablets as soon as possible
• Drugs that act directly on the renin-angiotensin system can cause injury and death to the developing fetus
See WARNINGS, Fetal TOXICITY

Known Side Effects

10 documented side effects by frequency

Diarrhea

1-10%

Fatigue

1-10%

Dizziness

1-10%

Shortness of Breath

1-10%

Nausea

1-10%

Weakness

1-10%

Low Blood Pressure

1-10%

Vomiting

1-10%

Falls

1-10%

Headache

1-10%

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Formulations

Dosage Forms

Tablet

Route

Oral