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Brand names: Fulvestrant, Faslodex
12.1 Mechanism of Action Many breast cancers have estrogen receptors (ER) and the growth of these tumors can be stimulated by estrogen. Fulvestrant is an estrogen receptor antagonist that binds to the estrogen receptor in a competitive manner with affinity comparable to that of estradiol and downregulates the ER protein in human breast cancer cells. In vitro studies demonstrated that fulvestrant is a reversible inhibitor of the growth of tamoxifen-resistant, as well as estrogen-sensitive human breast cancer (MCF-7) cell lines. In in vivo tumor studies, fulvestrant delayed the establishment of tumors from xenografts of human breast cancer MCF-7 cells in nude mice. Fulvestrant inhibited the growth of established MCF-7 xenografts and of tamoxifen-resistant breast tumor xenografts. Fulvestrant showed no agonist-type effects in in vivo uterotrophic assays in immature or ovariectomized mice and rats. In in vivo studies in immature rats and ovariectomized monkeys, fulvestrant blocked the uter
Contraindications
6 documented side effects by frequency
9 Reddit threads analysed for FULVESTRANT
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Avg Post Score
71 upvotes
Most discussed side effects in community
**What Is [G1 Therapeutics](https://www.g1therapeutics.com) & what do they do?** * G1 Therapeutics, Inc. engages in the development of small molecule therapeutics for the treatment of patients with cancer. Its products pipeline includes trilaciclib, rintodestrant, and lerociclib. * Trilacicl
Based on the title I guess you can say this DD is for all the perverted apes out here I thought about not writing anymore DD's, but due to the presence of [u/joeskunk](https://www.reddit.com/u/joeskunk/)'s massive big dongus brain I decided it would be a nice challenge to race him to multibagger cal
[Sauce](https://www.scribd.com/document/391342332/Reuters-US-En-Oct-22-2018) #TOP NEWS • Halliburton third-quarter profit edges past estimates Halliburton's third-quarter profit edged past analysts' estimates, as tight pipeline capacity in the top Permian basin led to fewer well completions. • KKR-b
For those of you who have followed my saga, I have now reached a level of bullshit that shocks even me. For those who haven’t, I’ll generally summarize. [I have posted this on multiple platforms.] I am currently existing somewhere between relief and raging fury. I finished treatment (BMx, AC/T, radi
Update. I posted a little while ago about being down. Met with my MO to go over PET scan. The bad news is my cancer has spread, so after nearly 2 years on my first line of treatment I have the dreaded progress. The average progression free survival (PFS) on that treatment is 2 years so I guess it c
I’m new here.. was dx 9/22 with stage 1b at 36 when my babies were 3 and 5. I had DIEP flap surgery 9/25 and had a rough recovery. My back and hips were in so much pain. I advocated for scans after failed PT and pain meds. In Dec 2025 i go the news of a questionable lumbar MRI but drs wanted to rule
Hi there, I'll start by introducing myself and giving a little background. I'm almost 39F with two young kids (6.5M, 4F). I was initially diagnosed back in March 2021 with stage 3 BC that was ++-. We went after it aggressively, first with neoadjuvent AC-T protocol, then a DMX, followed by 6 weeks
Well I've had 6 months of containment of my brain metastatic breast cancer, but scans this week shows new growth. Stopping kadcyla and neratinib, restarting herceptin, starting abemaciclib and fulvestrant, and looking into gamma knife radiation. Really not liking the idea of more radiation treatme
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Dosage Forms
Tablet
Route
Intramuscular