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Brand names: Gemcitabine
12.1 Mechanism of Action Gemcitabine kills cells undergoing DNA synthesis and blocks the progression of cells through the G1/S-phase boundary. Gemcitabine is metabolized by nucleoside kinases to diphosphate (dFdCDP) and triphosphate (dFdCTP) nucleosides. Gemcitabine diphosphate inhibits ribonucleotide reductase, an enzyme responsible for catalyzing the reactions that generate deoxynucleoside triphosphates for DNA synthesis, resulting in reductions in deoxynucleotide concentrations, including dCTP. Gemcitabine triphosphate competes with dCTP for incorporation into DNA. The reduction in the intracellular concentration of dCTP by the action of the diphosphate enhances the incorporation of gemcitabine triphosphate into DNA (self-potentiation). After the gemcitabine nucleotide is incorporated into DNA, only one additional nucleotide is added to the growing DNA strands which eventually results in the initiation of apoptotic cell death.
7 documented side effects by frequency
8 Reddit threads analysed for GEMCITABINE
Overall Sentiment
Mixed
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0
Avg Post Score
41 upvotes
Most discussed side effects in community
A new scientific review on cannabis and cancer concludes that a variety of cannabinoids—including delta-9 THC, CBD and cannabigerol (CBG)—”show promising potential as anticancer agents through various mechanisms,” for example by limiting the growth and spread of tumors. But authors acknowledged that
TLDR at the bottom. If you are a researcher, student, practitioner, etc., and you want to help our projects, feel free to send us a DM and we can arrange that :) *\[We want to give a special thanks to the new members and donors of the CRC who were able to make this project possible. We will continue
My husband (41, M) was just diagnosed in November with stage 4 cholangiocarcinoma. We have a 19 month old son and we had our lovely wedding in September. We’re shocked and devastated. His metastasis is extensive. He just started cisplatin and gemcitabine. He also tested MSI-high positive, making him
My mother's 4-month battle with pancreatic cancer ended recently. My family and I are devastated, as she was the backbone of our family, and a light loved by so many. While I'm glad her suffering didn't last too long, I wonder if we could have ended up somewhere different if we had made different ch
In the Amyris patent „VACCINE ADJUVANTS AND METHODS OF SYNTHESIZING AND USING THE SAME“ (1) is described in detail the ways in which future cancer vaccines could work. In the Cancer platforms specified by Immunitybio (IBRX) besides cancer vaccine, one of the platform is the use of cancer drugs. The
Mum was diagnosed with stage IV & mets to the liver back in August 2022. She has been on Gemcitabine+Abraxane since September. She received her 3rd scan update this week. The first showed not much change, the 2nd showed that the pancreatic tumour had gotten smaller and the 3rd has shown that bot
Hello, Wanted to get everyone's opinion on how you dispose of a catheter bags containing chemotherapy (mitomycin, gemcitabine, etc) after bladder instillation. I know some institutions will have the patient empty into a toilet and then will clean the toilets between patients, but I'm wondering speci
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14 available comparisons
Dosage Forms
Tablet
Route
Intravenous