IDARUBICIN HYDROCHLORIDE

Electrolyte / Mineral

Brand names: Idamycin PFS

Intravenous

Mechanism of Action

12.1 Mechanism of Action Idarubicin hydrochloride has antimitotic and cytotoxic activity through forming complexes with the DNA, inhibiting nucleic acid synthesis, inhibiting topoisomerase II activity, and producing DNA-damaging free radicals.

Indications

See full prescribing information

Contraindications

• 4 CONTRAINDICATIONS None. None. (4)

FDA Warnings

5 WARNINGS AND PRECAUTIONS • Myelosuppression : Severe myelosuppression resulting in severe infection, septic shock, hemorrhage, or death may occur
Advise patients of the potential risk to a fetus and to use effective contraception
In pediatric patients, anthracycline-induced cardiomyopathy included impaired left ventricular systolic performance, reduced contractility, congestive heart failure, or death
The risk of cardiomyopathy is generally proportional to the cumulative exposure to anthracycline drugs

Known Side Effects

3 documented side effects by frequency

Fever

1-10%

Nausea

0.1-1%

Drug Not Working

0.1-1%

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Compare With

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Formulations

Dosage Forms

Tablet

Route

Intravenous