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Brand names: Imatinib Mesylate, Gleevec
12.1 Mechanism of Action Imatinib mesylate is a protein-tyrosine kinase inhibitor that inhibits the BCR-ABL tyrosine kinase, the constitutive abnormal tyrosine kinase created by the Philadelphia chromosome abnormality in CML. Imatinib inhibits proliferation and induces apoptosis in BCR-ABL positive cell lines as well as fresh leukemic cells from Philadelphia chromosome positive chronic myeloid leukemia. Imatinib inhibits colony formation in assays using ex vivo peripheral blood and bone marrow samples from CML patients. In vivo , imatinib inhibits tumor growth of BCR-ABL transfected murine myeloid cells as well as BCR-ABL positive leukemia lines derived from CML patients in blast crisis. Imatinib is also an inhibitor of the receptor tyrosine kinases for platelet-derived growth factor (PDGF) and stem cell factor (SCF), c-Kit, and inhibits PDGF- and SCF-mediated cellular events. In vitro , imatinib inhibits proliferation and induces apoptosis in GIST cells, which express an activating c-
Contraindications
10 documented side effects by frequency
9 Reddit threads analysed for IMATINIB
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Most discussed side effects in community
Over the past few years, a growing number of clinicians and researchers have recognized that mast cell activation syndrome may play a significant role in post-COVID and Long COVID illness. Many people with ongoing symptoms, fatigue, dysautonomia, neuropathy, allergic-type reactions, and hypersensiti
I came across [Medical Nihilism](https://www.amazon.com/Medical-Nihilism-Jacob-Stegenga/dp/0198747047) in the SSC comments section, where someone begged Scott to review it. It looked interesting, and I thought "if Scott won't review it, maybe I will." The author, Jacob Stegenga, is a philosopher of
Finally got my most recent BCR-ABL1 results. I was 83% on 28 July at diagnosis, by mid September I was 43.3% and I was in again yesterday to find out my results from early November. Unbelievably I got down to 0.2% and I’m stunned. Back in at the end of January and we’re going to reduce my dose of I
I noticed that most of the research being shared on $SLS is mostly either technical analysis, or news heavy. With all the trading, analysis, and excitement that we do/feel in a month, it's easy to forget what's really driving the growth and development of this company: It's people. I wanted to take
EDIT: I just want to say a huge thank you to everyone who’s taken the time to reply to this. I wrote it late last night, went to bed and was so touched to wake up and see so much support. Thank you to those of you who have been through this yourselves and have shared your experiences. I really hope
My wife (age 36) at the time was first diagnosed with BCR-ABL positive acute lymphoblastic leukemia (ALL) B CELL in 2016. She went into remission but relapsed after two years. She had her first allogeneic bone marrow transplant from her sister. Unfortunately, she relapsed again after five years of
What a wild ride it’s been. Went to the docs with what I thought was thyroiditis only for Defcon 1 to kick in a day later when the bloods came back. Had zero symptoms other than maybe a tiny bit of fatigue that I just put down to the stresses of life and just getting older. Things really happened q
Over the past few years, a growing number of clinicians and researchers have recognized that mast cell activation syndrome may play a significant role in post-COVID and Long COVID illness. Many people with ongoing symptoms, fatigue, dysautonomia, neuropathy, allergic-type reactions, and hypersensiti
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Dosage Forms
Tablet
Route
Oral