IMIPENEM AND CILASTATIN

Other

Brand names: Imipenem and Cilastatin

Intravenous

Mechanism of Action

12.1 Mechanism of Action Imipenem and cilastatin for injection is a combination of imipenem and cilastatin. Imipenem is a penem antibacterial drug [see Clinical Pharmacology (12.4)] . Cilastatin is a renal dehydropeptidase inhibitor that limits the renal metabolism of imipenem.

Indications

1 INDICATIONS AND USAGE Imipenem and Cilastatin for Injection

USP for intravenous use is a combination of imipenem

a penem antibacterial

and cilastatin

a renal dehydropeptidase inhibitor

USP is not indicated in patients with meningitis because safety and efficacy have not been established ( 1.9 ). • Imipenem and Cilastatin for Injection

FDA Warnings

5 WARNINGS AND PRECAUTIONS • Hypersensitivity Reactions: Serious and occasionally fatal hypersensitivity (anaphylactic) reactions have been reported in patients receiving therapy with beta-lactams
The valproic acid concentrations may drop below the therapeutic range as a result of this interaction, therefore increasing the risk of breakthrough seizures
• Clostridioides difficile-Associated Diarrhea (CDAD): has been reported with use of imipenem and cilastatin for injection and may range in severity from mild diarrhea to fatal colitis
1 Hypersensitivity Reactions Serious and occasionally fatal hypersensitivity (anaphylactic) reactions have been reported in patients receiving therapy with beta-lactams

Known Side Effects

4 documented side effects by frequency

Drug Not Working

>10%

Fever

1-10%

Nausea

0.1-1%

Vomiting

0.1-1%

Community Discussions

No community discussions found for IMIPENEM AND CILASTATIN yet.

Compare With

0 available comparisons

No comparisons yet.

Formulations

Dosage Forms

Tablet

Route

Intravenous