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Brand names: Itovebi
12.1 Mechanism of Action Inavolisib is an inhibitor of phosphatidylinositol 3-kinase (PI3K) with inhibitory activity predominantly against PI3Kα. In vitro, inavolisib induced the degradation of mutated PI3K catalytic alpha subunit p110α (encoded by the PIK3CA gene), inhibited phosphorylation of the downstream target AKT, reduced cellular proliferation, and induced apoptosis in PIK3CA -mutated breast cancer cell lines. In vivo, inavolisib reduced tumor growth in PIK3CA -mutated, estrogen receptor-positive, breast cancer xenograft models. The combination of inavolisib with palbociclib and fulvestrant increased tumor growth inhibition compared to each treatment alone or the doublet combinations.
Contraindications
6 documented side effects by frequency
3 Reddit threads analysed for INAVOLISIB
Overall Sentiment
Mixed
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Avg Post Score
8 upvotes
Most discussed side effects in community
Has anyone been diagnosed with stage four breast cancer that has spread only to the liver with some smaller tumors. In my case, I have three tumors and I have been researching this new procedure. I don’t know if anybody had other procedures which exist that reduced the tumor burden in the liver. I h
Hello fellow warriors. 💪 (63F ER/PR+ HER2-, Mets to lots of bones, skull, and small lesion on liver) I've been on Kisqali/Fulvestrant/Zometa, just finished 4th cycle. I was tolerating current treatments fairly well. But, I just got Genomic tumor testing back and shows I have the PIK3ca mutation now
Has anybody had this treatment or been offered it. I have recently had it even though oncologist were not against it, but not particularly for it. It’s very new and there’s not a lot of data. For 6 months Ibrance Itovbi Fulvestant.. now on XELODA. Interventional radiologist felt it could help. I hav
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Dosage Forms
Tablet
Route
Oral