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Brand names: Indomethacin
12.1 Mechanism of Action Indomethacin has analgesic, anti-inflammatory, and antipyretic properties. The mechanism of action of indomethacin capsules, like that of other NSAIDs, is not completely understood but involves inhibition of cyclooxygenase (COX-1 and COX-2). Indomethacin is a potent inhibitor of prostaglandin synthesis in vitro . Indomethacin concentrations reached during therapy have produced in vivo effects. Prostaglandins sensitize afferent nerves and potentiate the action of bradykinin in inducing pain in animal models. Prostaglandins are mediators of inflammation. Because indomethacin is an inhibitor of prostaglandin synthesis, its mode of action may be due to a decrease of prostaglandins in peripheral tissues.
Contraindications
13 documented side effects by frequency
6 Reddit threads analysed for INDOMETHACIN
Overall Sentiment
Mixed
Comparison Threads
0
Avg Post Score
13 upvotes
Most discussed side effects in community
How do you guys handle beers’ list issues in retail? My chain has now made it a hard-stop contraindication and our general guidelines for those are that we have to document that we spoke to the provider and discuss the issue. The problem is the majority of these are for acute conditions, promethazin
Today I was counseling a customer on Indomethacin and when I was done I asked him if he had any questions. He did but because of his accent when I asked if there were any reactions I heard he say “Any erections?”
Has any pharmacist seen such an indication for indomethacin? So it looks like this is used for headaches associated with sexual activity? But the most common side effect of indomethacin is headache! ​
I have a patient who is continuing on a compounded medication of dihydroergotamine 10 mg, indomethacin 50mg, metoclopramide 10mg, and caffeine 30mg. Has anyone heard of this combination or know anymore about it? Not even sure where to start writing this or anything.
I work at an educational institution. Today, I made an indomethacin (placebo) 5mg/mL suspension using placebo powder, sucrose, methylcellulose, and purified water. I thought suspending agent like methylcellulose is going to slow down sedimentation of the placebo powder, but I never expected to see s
Physician here. I saw a pt in clinic today who showed me a pic of a med he took for his back pain (from Mexico). It was a tablet with a steroid(cant remember which one but it was 0.5mg), 25mg indomethacin, and methocarbamol (don’t remember dose). It just got me and one of my partners talking. What
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20 available comparisons
Dosage Forms
Tablet
Route
Oral