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Brand names: INFLECTRA, Remicade
12.1 Mechanism of Action Infliximab products neutralize the biological activity of TNFα by binding with high affinity to the soluble and transmembrane forms of TNFα and inhibit binding of TNFα with its receptors. Infliximab products do not neutralize TNFβ (lymphotoxin-α), a related cytokine that utilizes the same receptors as TNFα. Biological activities attributed to TNFα include: induction of proinflammatory cytokines such as interleukins (IL) 1 and 6, enhancement of leukocyte migration by increasing endothelial layer permeability and expression of adhesion molecules by endothelial cells and leukocytes, activation of neutrophil and eosinophil functional activity, induction of acute phase reactants and other liver proteins, as well as tissue degrading enzymes produced by synoviocytes and/or chondrocytes. Cells expressing transmembrane TNFα bound by infliximab products can be lysed in vitro or in vivo . Infliximab products inhibit the functional activity of TNFα in a wide variety of in
Contraindications
10 documented side effects by frequency
10 Reddit threads analysed for INFLIXIMAB-DYYB
Overall Sentiment
Mixed
Comparison Threads
0
Avg Post Score
47 upvotes
Most discussed side effects in community
I’m a hospital worker so I was able to get the vaccine (Pfizer brand) today. I wanted to share my experience with everyone as I had a lot of fear and doubts about getting it myself. Everything went extremely well, so far I have no side effects at all and it’s been about 4 hours. My arm doesn’t even
I’m bored and have a funny story, so I thought I’d share. I’m in the worst Crohn’s flare up thing of my life, which was brought on by a series of traumatic experiences. Inflectra/Remicade/Infliximab doesn’t work on me anymore apparently and neither do steroids, so my doctor changed me to Entivio re
Hi everyone, I had the idea of putting together a community developed survey for those of us diagnosed with Crohn's disease. The survey could allow us to gain insights into many different aspects of the Crohn's community. I am curious if anyone has some questions they would like to be included, if
Long of the short I was diagnosed with UC in 2020. Took mesalamine until December of 2025. Two flares one in October 2024 (lost 30 lbs) second and ongoing flare July 2025-present. I can’t gain any weight back. I started Inflectra in Feb of 2026 and just had my second dose. I am currently in a flare
I'm starting on Inflectra on Friday, and I'm a bit nervous, wondering: what might I expect? What I can bring to make the experience better? I have Crohn's and perianal disease (with two draining setons from a recent surgery). Planning on bringing some audiobooks, my donut pillow, and some snacks, bu
QUICK BIO: Was first diagnosed with UC in 2015. Was fairly moderate until 2020, when worsening symptoms led me to starting infusions of Inflectra. Was on that steady for nearly three years until my GI took me off of it because my inflammation markers still weren't looking good enough. I was on zero
Community discussions are sourced from public Reddit threads. Content reflects individual opinions and is not medical advice.
11 available comparisons
Dosage Forms
Tablet
Route
Intravenous