IODIXANOL

Diagnostic Agent

Brand names: Iodixanol

Intravascular

Mechanism of Action

12.1 Mechanism of Action Intravascular injection of iodixanol opacifies vessels in the path of flow of the contrast agent, permitting visualization of internal structures. In imaging of the body, iodinated contrast agents diffuse from the vascular into the extravascular space. In a normal brain with an intact blood-brain barrier, contrast does not diffuse into the extravascular space. In patients with a disrupted blood- brain barrier, contrast agent accumulates in the interstitial space in the region of disruption.

Indications

peripheral arteriography

visceral arteriography

and cerebral arteriography (320 mg Iodine/mL). Pediatric patients less than 12 years of age Angiocardiography

cerebral arteriography

peripheral arteriography

visceral arteriography

Contraindications

• 4 CONTRAINDICATIONS Iodixanol is contraindicated for intrathecal use [see Warnings and Precautions (5.1) ] : Not indicated for intrathecal use. ( 4 )

FDA Warnings

5 WARNINGS AND PRECAUTIONS Hypersensitivity Reactions: Life-threatening or fatal reactions can occur
Minimize dose and maintain adequate hydration to minimize risk
4 ) Thyroid Dysfunction in Pediatric Patients 0 to 3 Years of Age: Individualize thyroid function monitoring based on risk factors such as prematurity
1 Risks Associated with Inadvertent Intrathecal Administration Iodixanol is for intravascular use only and is contraindicated for intrathecal use [see Contraindications (4) and Dosage and Administration (2

Known Side Effects

6 documented side effects by frequency

Itching

>10%

Rash

>10%

Shortness of Breath

1-10%

Nausea

1-10%

Low Blood Pressure

1-10%

Vomiting

1-10%

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Compare With

11 available comparisons

Formulations

Dosage Forms

Tablet

Route

Intravascular