IRBESARTAN

ARB

Brand names: Irbesartan, Avapro, Avalide

Oral

Mechanism of Action

ARB agent

Indications

1 INDICATIONS AND USAGE Irbesartan tablets are an angiotensin II receptor blocker (ARB) indicated for: Treatment of hypertension

to lower blood pressure. Lowering blood pressure reduces the risk of fatal and nonfatal cardiovascular events

primarily strokes and myocardial infarctions. ( 1.1 ) Treatment of diabetic nephropathy in hypertensive patients with type 2 diabetes

an elevated serum creatinine

and proteinuria. ( 1.2 ) 1.1 Hypertension Irbesartan tablets are indicated for the treatment of hypertension

to lower blood pressure. Lowering blood pressure lowers the risk of fatal and non-fatal cardiovascular (CV) events

FDA Warnings

5 WARNINGS AND PRECAUTIONS Hypotension: Correct volume or salt depletion prior to administration
Use of drugs that act on the renin-angiotensin system during the second and third trimesters of pregnancy reduces fetal renal function and increases fetal and neonatal morbidity and death
Potential neonatal adverse effects include skull hypoplasia, anuria, hypotension, renal failure, and death
, patients with renal artery stenosis, chronic kidney disease, severe heart failure, or volume depletion) may be at particular risk of developing acute renal failure or death on irbesartan tablets

Known Side Effects

12 documented side effects by frequency

Nausea

1-10%

Fatigue

1-10%

Diarrhea

1-10%

Drug Not Working

1-10%

Dizziness

1-10%

Shortness of Breath

1-10%

Headache

1-10%

Falls

1-10%

Weakness

1-10%

General Unwellness

1-10%

Vomiting

1-10%

High Blood Pressure

1-10%

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Formulations

Dosage Forms

Tablet

Route

Oral