KETAMINE HYDROCHLORIDE

Electrolyte / Mineral

Brand names: Ketalar

Intramuscular, Intravenous

Mechanism of Action

12.1 Mechanism of Action KETALAR, a racemic mixture of ketamine, is a non-selective, non-competitive antagonist of the N-methyl-D-aspartate (NMDA) receptor, an ionotropic glutamate receptor. The major circulating metabolite of ketamine (norketamine) demonstrated activity at the same receptor with less affinity. Norketamine is about 1/3 as active as ketamine in reducing halothane requirements (MAC) of the rat.

Indications

See full prescribing information

FDA Warnings

5 WARNINGS AND PRECAUTIONS Hemodynamic Instability: Monitor vital signs and cardiac function during KETALAR administration
2 ) Risk of Respiratory Depression: May occur with overdosage or too rapid a rate of administration
3 ) Risks of KETALAR alone for Procedures of the Pharynx, Larynx, or Bronchial Tree : Pharyngeal and laryngeal reflexes are not suppressed with KETALAR when it is used alone
KETALAR is contraindicated in patients for whom a significant elevation of blood pressure would constitute a serious hazard [see Contraindications ( 4 )]

Known Side Effects

8 documented side effects by frequency

Drug Not Working

>10%

Nausea

1-10%

Headache

1-10%

Diarrhea

1-10%

Shortness of Breath

1-10%

Fatigue

0.1-1%

Low Blood Pressure

0.1-1%

Vomiting

0.1-1%

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Compare With

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Formulations

Dosage Forms

Tablet

Route

Intramuscular, Intravenous