KETOPROFEN

Other

Brand names: Ketoprofen

Oral

Mechanism of Action

Pharmacodynamics Ketoprofen is a racemate with only the S enantiomer possessing pharmacological activity. The enantiomers have similar concentration time curves and do not appear to interact with one another. An analgesic effect‑concentration relationship for ketoprofen was established in an oral surgery pain study with ketoprofen capsules. The effect-site rate constant (K e0 ) was estimated to be 0.9 hour -1 (95% confidence limits: 0 to 2.1), and the concentration (Ce 50 ) of ketoprofen that pr

Indications

See full prescribing information

Contraindications

• urticaria
• or allergic-type reactions after taking aspirin or other NSAIDs. Severe
• rarely fatal

FDA Warnings

Cardiovascular Thrombotic Events • Nonsteroidal anti-inflammatory drugs (NSAIDs) cause an increased risk of serious cardiovascular thrombotic events, including myocardial infarction and stroke, which can be fatal
This risk may occur early in treatment and may increase with duration of use (see WARNINGS and PRECAUTIONS )
• Ketoprofen extended-release capsules are contraindicated in the setting of coronary artery bypass graft (CABG) surgery (see CONTRAINDICATIONS and WARNINGS )
Gastrointestinal Risk • NSAIDs cause an increased risk of serious gastrointestinal adverse events including bleeding, ulceration, and perforation of the stomach or intestines, which can be fatal

Known Side Effects

9 documented side effects by frequency

Headache

>10%

Fatigue

1-10%

Drug Not Working

1-10%

Nausea

1-10%

Fever

1-10%

Back Pain

1-10%

Excessive Sweating

1-10%

Diarrhea

1-10%

Constipation

1-10%

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Formulations

Dosage Forms

Tablet

Route

Oral