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Brand names: Lamotrigine, Lamictal
12.1 Mechanism of Action The precise mechanism(s) by which lamotrigine exerts its anticonvulsant action are unknown. In animal models designed to detect anticonvulsant activity, lamotrigine was effective in preventing seizure spread in the maximum electroshock (MES) and pentylenetetrazol (scMet) tests, and prevented seizures in the visually and electrically evoked after-discharge (EEAD) tests for antiepileptic activity. Lamotrigine also displayed inhibitory properties in the kindling model in rats both during kindling development and in the fully kindled state. The relevance of these models to human epilepsy, however, is not known. One proposed mechanism of action of lamotrigine, the relevance of which remains to be established in humans, involves an effect on sodium channels. In vitro pharmacological studies suggest that lamotrigine inhibits voltage-sensitive sodium channels, thereby stabilizing neuronal membranes and consequently modulating presynaptic transmitter release of excitato
Contraindications
11 documented side effects by frequency
15 Reddit threads analysed for LAMOTRIGINE
Overall Sentiment
Mixed
Comparison Threads
0
Avg Post Score
242 upvotes
Most discussed side effects in community
I’m a writer. Maybe not a successful one at this point in my life, but it’s what I identify as. Writing has been such a big part of my life for as long as I can remember. Writing is one of the few things I am confident I can do, regardless of my mental state, and it has been my personal therapy for
Edit: I just got on new medication last week. I’m not looking to get attention I’m truly asking for help. I also just went through an episode of hitting myself. Which truly felt like it helped to let that out. I know that sounds terrible but I feel better now. I feel bad that my dog just saw me do a
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28 available comparisons
Dosage Forms
Tablet
Route
Oral