LANTHANUM CARBONATE

Other

Brand names: Lanthanum carbonate

Oral

Mechanism of Action

12.1 Mechanism of Action Lanthanum carbonate is a phosphate binder that reduces absorption of phosphate by forming insoluble lanthanum phosphate complexes that pass through the GI tract unabsorbed. Both serum phosphate and calcium phosphate product are reduced as a consequence of the reduced dietary phosphate absorption.

Indications

removal of phosphate by dialysis

Contraindications

• 4 CONTRAINDICATIONS Contraindicated in patients with: hypersensitivity to Lanthanum carbonate or to any ingredient in the formulation. bowel obstruction
• including ileus and fecal impaction. Hypersensitivity to Lanthanum carbonate or to any ingredient in the formulation. ( 4 ) Bowel obstruction
• ileus
• and fecal impaction. ( 4 )

FDA Warnings

5 WARNINGS AND PRECAUTIONS Serious cases of gastrointestinal obstruction, ileus, subileus, gastrointestinal perforation, and fecal impaction
Risks include altered gastrointestinal anatomy, hypomotility disorders, and concomitant medications
1 Gastrointestinal Adverse Effects Serious cases of gastrointestinal obstruction, ileus, subileus, gastrointestinal perforation, and fecal impaction have been reported in patients taking lanthanum, some requiring surgery or hospitalization
Risk factors for gastrointestinal obstruction and gastrointestinal perforation identified from post-marketing reports in patients taking lanthanum carbonate chewable tablets include abnormal gastrointestinal anatomy (e

Known Side Effects

4 documented side effects by frequency

Nausea

1-10%

Vomiting

1-10%

Constipation

1-10%

Abdominal Pain

1-10%

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Formulations

Dosage Forms

Tablet

Route

Oral