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Brand names: VITRAKVI
12.1 Mechanism of Action Larotrectinib is an inhibitor of the tropomyosin receptor kinases (TRK), TRKA, TRKB, and TRKC. In a broad panel of purified enzyme assays, larotrectinib inhibited TRKA, TRKB, and TRKC with IC 50 values between 5-11 nM. One other kinase TNK2 was inhibited at approximately 100-fold higher concentration. TRKA, B, and C are encoded by the genes NTRK1, NTRK2, and NTRK3. Chromosomal rearrangements involving in-frame fusions of these genes with various partners can result in constitutively-activated chimeric TRK fusion proteins that can act as an oncogenic driver, promoting cell proliferation and survival in tumor cell lines. In in vitro and in vivo tumor models, larotrectinib demonstrated anti-tumor activity in cells with constitutive activation of TRK proteins resulting from gene fusions, deletion of a protein regulatory domain, or in cells with TRK protein overexpression. Larotrectinib had minimal activity in cell lines with point mutations in the TRKA kinase domai
Contraindications
8 documented side effects by frequency
5 Reddit threads analysed for LAROTRECTINIB
Overall Sentiment
Mixed
Comparison Threads
0
Avg Post Score
41 upvotes
Most discussed side effects in community
#/r/worldnews - **/u/glasier** **Manafort held secret talks with Assange in Ecuadorian embassy** [**Comments**](/r/worldnews/comments/a0vb9g/manafort_held_secret_talks_with_assange_in/) || [**Link**](https://www.theguardian.com/us-news/2018/nov/27/manafort-held-secret-talks-with-assange-in-ecuador
Hi everyone. I was the one who posted earlier this week asking about port experiences and doing chemo 5 days in a row. I met with my oncologist yesterday and literally everything has changed. They completed a gene fusion test on my tumor and I'm the first person with this type of presentation of ca
Hello everyone, I was a relatively healthy 33 year old until around 4 months ago when we received the news most people dread. I feel it’s very important to share my story as unfortunately, I help account for the very rare 1% of thyroid cancers and have had a relatively rough route to diagnosis and
Has anybody had experience with this drug? They are taking me off lenvima in favor of this as the lenvima hasn’t shrunk the tumor much and I have the mutation this targets.
Hi everyone! I just read about **Vitrakvi,** has anyone has experience with it? I've been actively looking for treatments for the daughter of a friend of my father. Each time I think about that we are the same age and she has struggled with cancer almost her entire life, I just wish I could help h
Community discussions are sourced from public Reddit threads. Content reflects individual opinions and is not medical advice.
15 available comparisons
Dosage Forms
Tablet
Route
Oral, Oropharyngeal