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Brand names: Lenalidomide, Revlimid
12.1 Mechanism of Action Lenalidomide is an analogue of thalidomide with immunomodulatory, antiangiogenic, and antineoplastic properties. Cellular activities of lenalidomide are mediated through its target cereblon, a component of a cullin ring E3 ubiquitin ligase enzyme complex. In vitro , in the presence of drug, substrate proteins (including Aiolos, Ikaros, and CK1α) are targeted for ubiquitination and subsequent degradation leading to direct cytotoxic and immunomodulatory effects. Lenalidomide inhibits proliferation and induces apoptosis of certain hematopoietic tumor cells including MM, mantle cell lymphoma, and del (5q) myelodysplastic syndromes in vitro . Lenalidomide causes a delay in tumor growth in some in vivo nonclinical hematopoietic tumor models including MM. Immunomodulatory properties of lenalidomide include increased number and activation of T cells and natural killer (NK) cells leading to direct and enhanced antibody-dependent cell-mediated cytotoxicity (ADCC) via inc
Contraindications
6 documented side effects by frequency
9 Reddit threads analysed for LENALIDOMIDE
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Mixed
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52 upvotes
Most discussed side effects in community
Hello. Last year, my mother was diagnosed with Multiple Myeloma, a type of bone marrow/blood cancer. She's not responding well to her current drugs and the doctor has recommended switching to Lenalidomide. Unfortunately, the non-generic version (Revlimid) is extremely expensive and we are unable to
I know this might be a bit of an unusual post. But I’ve been on chemo/immuno drugs for the past ~2 years now, along with a stem cell (aka bone marrow) transplant last year. But throughout working hard to keep my running up when I can. It’s hard to find people going through similar experiences and h
We're very sorry you've joined this very stupid club, and hope this sub can be a valuable resource, especially for those aspects of the journey that sometimes aren't as well covered by the medical profession, in particular the *experience* of having lymphoma and being treated for it. While we encour
Hi everyone, I’ve been reading this forum for a while and used it as a research channel in the early days of my dad’s diagnosis, but I hadn’t posted until now. I wanted to share my dad’s story - not just to honour him, but also to connect with others who may have walked a similar path or carry the s
Today i had the pleasure of trying to confirm an interaction they inquired about. I told the person answering the phone i wanted to clarify a drug interaction of which they called about. He said "i dont know what you mean by interaction". Seriously? Every time i call its hold times of about an hou
Hi Team, I was getting a lot of questions about this addition / transition off. My first thoughts - Mikael Dolsten was a great board member, sad to see him transition off, yet with that being said let's look at timelines. If there are exploratory talks, those typically can happen when there is a con
Hi all. I lost my dad in October to MM. I have questions about what happened - it was all very sudden. If anyone has any insight or similar experiences I'd be interested to hear it. Long story to follow. Thanks to anyone who takes the time to read. My dad was my guy. -he was diagnosed in April 2019
DLBCL is a curable disease in most patients, and the data online can be hard to interpret as there is great variability in patients' age, performance status, burden of disease and subtype of DLBCL. Very broadly \~70-75% (some series a bit lower and in some a bit higher) of patients have a disease
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Dosage Forms
Tablet
Route
Oral