Medical Disclaimer: This site provides informational comparisons only and is not a substitute for professional medical advice, diagnosis, or treatment. Always consult your physician or pharmacist before making medication decisions.
Brand names: Levetiracetam, Keppra
12.1 Mechanism of Action The precise mechanism(s) by which levetiracetam exerts its antiepileptic effect is unknown. A saturable and stereoselective neuronal binding site in rat brain tissue has been described for levetiracetam. Experimental data indicate that this binding site is the synaptic vesicle protein SV2A, thought to be involved in the regulation of vesicle exocytosis. Although the molecular significance of levetiracetam binding to SV2A is not understood, levetiracetam and related analogs showed a rank order of affinity for SV2A which correlated with the potency of their antiseizure activity in audiogenic seizure-prone mice. These findings suggest that the interaction of levetiracetam with the SV2A protein may contribute to the antiepileptic mechanism of action of the drug.
Contraindications
8 documented side effects by frequency
15 Reddit threads analysed for LEVETIRACETAM
Overall Sentiment
Mixed
Comparison Threads
0
Avg Post Score
101 upvotes
Most discussed side effects in community
Hi all, I’m a patient at one of the top migraine centers in the country (Diamond Headache Clinic in Chicago). They do a lot of off-label/ non-conventional treatments, so I feel like I have a pretty good list of known treatments. Feel free to add to it in the comments. Hope this helps someone!! THIS
I finally broke down and got these TimerCap caps from Amazon. I am really good about taking my meds usually, but I have been really sick this week and actually double dosed on accident. I can't stand those pill organizers, so I'm going to give these a shot. I attached photos so you can see that the
I hope the streak continues. I was diagnosed 3 years ago with Left TLE. I was having 2 grand Mal a month at the beginning and while they tweaked my meds it started varying. I’m on 2 meds (Levetiracetam, Oxcarbazepine) now and for the last year nothing has happened. Just this week for the first time
People seem to really dislike levetiracetam here. For me it’s been great. No side effects at all, if you don’t count that it totally took away my motion sickness, which I had even before epilepsy. Fingers crossed for another six months and I’ll get my drivers license back!
While other drugs clear existing plaques, levetiracetam (keppra) prevents production of toxic amyloid beta peptides https://news.northwestern.edu/stories/2026/02/common-anti-seizure-drug-prevents-alzheimers-plaques-from-forming I take Keppra. It keeps the seizures at bay, but it also makes me drowsy
I am angry, I can’t remember anything literally 2 seconds later, I can’t talk properly, I keep stuttering, I have ZERO thoughts ZERO. empty brain. it’s managing my seizures, but I don’t like how im feeling on it at all. Did you guys switch from it one that managed your seizures and wasn’t as enragi
(18F) I’m just wondering if anyone has any experiences similar to what I’m going through. I have complex partial seizures. The cause of these seizures is heterotopia in my brain. I have been taking keppra/levetiracetam for around 6 months now. It isn’t perfect but has made massive improvements. I’m
I take 1000 mg of Keppra/Levetiracetam and 400 Lamictal/Lamotrigine. And I am so fucking tired all the time. There isn't a moment of my day that I couldn't lay down and just, fall asleep. My memory is bad enough that I'll forget what I was gonna say in the middle of saying it, or forget what someone
Community discussions are sourced from public Reddit threads. Content reflects individual opinions and is not medical advice.
14 available comparisons
Dosage Forms
Tablet
Route
Oral