LEVORPHANOL TARTRATE

Other

Brand names: Levorphanol Tartrate

Oral

Mechanism of Action

Mechanism of Action Levorphanol is a full opioid agonist and is relatively selective for the mu-opioid receptor, although it can bind to other opioid receptors at higher doses. The principal therapeutic action of levorphanol is analgesia. Like all full opioid agonists, there is no ceiling effect for analgesia with levorphanol. Clinically, dosage is titrated to provide adequate analgesia and may be limited by adverse reactions, including respiratory and CNS depression. The precise mechanism of the analgesic action is unknown. However, specific CNS opioid receptors for endogenous compounds with opioid-like activity have been identified throughout the brain and spinal cord and are thought to play a role in the analgesic effects of this drug.

Indications

abuse

and misuse with opioids

which can occur at any dosage or duration [see WARNINGS ]

reserve Levorphanol Tartrate Tablets for use in patients for whom alternative treatment options (e.g.

non-opioid analgesics): • Have not been tolerated or are not expected to be tolerated

Contraindications

• including paralytic ileus [see WARNINGS ] • Hypersensitivity to levorphanol or any of the formulation excipients (e.g.
• anaphylaxis) [see WARNINGS ]

FDA Warnings

WARNING: SERIOUS AND LIFE-THREATENING RISKS FROM USE OF LEVORPHANOL TARTRATE TABLETS Addiction, Abuse, and Misuse Because the use of Levorphanol Tartrate Tablets exposes patients and other users to the risks of opioid addiction, abuse, and misuse, which can lead to overdose and death, assess each patient’s risk prior to prescribing and reassess all patients regularly for the development of these behaviors and conditions [see WARNINGS ]
Life-Threatening Respiratory Depression Serious, life-threatening, or fatal respiratory depression may occur with use of Levorphanol Tartrate Tablets, especially during initiation or following a dosage increase
To reduce the risk of respiratory depression, proper dosing and titration of Levorphanol Tartrate Tablets are essential [see WARNINGS ]
Accidental Ingestion Accidental ingestion of even one dose of Levorphanol Tartrate Tablets, especially by children, can result in a fatal overdose of levorphanol [see WARNINGS ]

Known Side Effects

9 documented side effects by frequency

Drug Not Working

1-10%

Nausea

1-10%

Headache

1-10%

Diarrhea

1-10%

Excessive Sweating

1-10%

Anxiety

0.1-1%

Dizziness

0.1-1%

Vomiting

0.1-1%

Constipation

0.1-1%

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Formulations

Dosage Forms

Tablet

Route

Oral