LIDOCAINE AND PRILOCAINE

Other

Brand names: Lidocaine and prilocaine

Topical

Mechanism of Action

Mechanism of Action Lidocaine and prilocaine cream, 2.5%/2.5%, applied to intact skin under occlusive dressing, provides dermal analgesia by the release of lidocaine and prilocaine from the cream into the epidermal and dermal layers of the skin and by the accumulation of lidocaine and prilocaine in the vicinity of dermal pain receptors and nerve endings. Lidocaine and prilocaine are amide-type local anesthetic agents. Both lidocaine and prilocaine stabilize neuronal membranes by inhibiting the ionic fluxes required for the initiation and conduction of impulses, thereby effecting local anesthetic action. The onset, depth and duration of dermal analgesia on intact skin provided by lidocaine and prilocaine cream depend primarily on the duration of application. To provide sufficient analgesia for clinical procedures such as intravenous catheter placement and venipuncture, lidocaine and prilocaine cream should be applied under an occlusive dressing for at least 1 hour. To provide dermal ana

Indications

INDICATIONS AND USAGE Lidocaine and prilocaine cream USP

FDA Warnings

WARNINGS Application of lidocaine and prilocaine cream to larger areas or for longer times than those recommended could result in sufficient absorption of lidocaine and prilocaine resulting in serious adverse effects (see Individualization of Dose )
Although all patients are at risk for methemoglobinemia, patients with glucose-6-phosphate dehydrogenase deficiency, congenital or idiopathic methemoglobinemia, cardiac or pulmonary compromise, infants under 6 months of age and concurrent exposure to oxidizing agents or their metabolites are more susceptible to developing clinical manifestations of the condition
Methemoglobin levels may continue to rise; therefore, immediate treatment is required to avert more serious central nervous system and cardiovascular adverse effects, including seizures, coma, arrhythmias and death

Known Side Effects

9 documented side effects by frequency

Drug Not Working

>10%

Nausea

1-10%

Fatigue

1-10%

Headache

1-10%

Shortness of Breath

1-10%

Condition Worsened

0.1-1%

Diarrhea

0.1-1%

Vomiting

0.1-1%

Dizziness

0.1-1%

Community Discussions

No community discussions found for LIDOCAINE AND PRILOCAINE yet.

Compare With

0 available comparisons

No comparisons yet.

Formulations

Dosage Forms

Tablet

Route

Topical