LIOTHYRONINE SODIUM

Thyroid Hormone

Brand names: Liothyronine Sodium

Oral

Mechanism of Action

12.1 Mechanism of Action Thyroid hormones exert their physiologic actions through control of DNA transcription and protein synthesis. Triiodothyronine (T3) and L-thyroxine (T4) diffuse into the cell nucleus and bind to thyroid receptor proteins attached to DNA. This hormone nuclear receptor complex activates gene transcription and synthesis of messenger RNA and cytoplasmic proteins. The physiological actions of thyroid hormones are produced predominantly by T3, the majority of which (approximately 80%) is derived from T4 by deiodination in peripheral tissues.

Indications

1 INDICATIONS AND USAGE Liothyronine sodium tablets are an L-triiodothyronine (T3) indicated for: Hypothyroidism: As replacement in primary (thyroidal)

secondary (pituitary)

and tertiary (hypothalamic) congenital or acquired hypothyroidism ( 1.1 ) Pituitary Thyrotropin (Thyroid-Stimulating Hormone

secondary (pituitary)

and tertiary (hypothalamic) congenital or acquired hypothyroidism. 1.2 Pituitary Thyrotropin (Thyroid-Stimulating Hormone

FDA Warnings

5 WARNINGS AND PRECAUTIONS Cardiac adverse reactions in the elderly and in patients with underlying cardiovascular disease: Initiate liothyronine sodium tablets at less than the full replacement dose because of the increased risk of cardiac adverse reactions, including atrial fibrillation ( 2
Administer the minimum dose of liothyronine sodium tablets that achieves the desired clinical and biochemical response to mitigate against this risk

Known Side Effects

10 documented side effects by frequency

Drug Not Working

>10%

Headache

>10%

Fatigue

>10%

Nausea

1-10%

Shortness of Breath

1-10%

High Blood Pressure

1-10%

Weight Gain

1-10%

General Unwellness

1-10%

Dizziness

0.1-1%

Diarrhea

0.1-1%

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Compare With

4 available comparisons

Formulations

Dosage Forms

Tablet

Route

Oral