LOFEXIDINE HYDROCHLORIDE

Electrolyte / Mineral

Brand names: lofexidine hydrochloride

Oral

Mechanism of Action

12.1 Mechanism of Action Lofexidine is a central alpha-2 adrenergic agonist that binds to receptors on adrenergic neurons. This reduces the release of norepinephrine and decreases sympathetic tone.

Indications

See full prescribing information

Contraindications

• 4 CONTRAINDICATIONS None. None. ( 4 )

FDA Warnings

5 WARNINGS AND PRECAUTIONS Risk of Hypotension, Bradycardia, and Syncope : May cause a decrease in blood pressure, a decrease in pulse, and syncope
Monitor vital signs before dosing and advise patients on how to minimize the risk of these cardiovascular effects and manage symptoms, should they occur
2 ) Increased Risk of CNS Depression with Concomitant use of CNS Depressant Drugs: Lofexidine potentiate the CNS depressant effects of benzodiazepines and may potentiate the CNS depressant effects of alcohol, barbiturates, and other sedating drugs
3 ) Increased Risk of Opioid Overdose after Opioid Discontinuation: Patients who complete opioid discontinuation are at an increased risk of fatal overdose should they resume opioid use

Known Side Effects

12 documented side effects by frequency

Dizziness

>10%

Low Blood Pressure

1-10%

Drowsiness

1-10%

Shortness of Breath

1-10%

Diarrhea

1-10%

Dry Mouth

1-10%

Fatigue

1-10%

Insomnia

1-10%

General Unwellness

1-10%

Vomiting

1-10%

Nausea

1-10%

Falls

0.1-1%

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Formulations

Dosage Forms

Tablet

Route

Oral