LOMUSTINE

Other

Brand names: Gleostine

Oral

Mechanism of Action

12.1 Mechanism of Action Lomustine alkylates DNA and RNA. As with other nitrosoureas, it may also inhibit several key enzymatic processes by carbamoylation of amino acids in proteins.

Indications

1 INDICATIONS AND USAGE Gleostine is an alkylating drug indicated for the treatment of patients with: Brain tumors

primary and metastatic

following appropriate surgical and/or radiotherapeutic procedures. ( 1 ) Hodgkin's lymphoma in combination with other chemotherapies

Contraindications

• 4 CONTRAINDICATIONS None.

FDA Warnings

5 WARNINGS AND PRECAUTIONS Pulmonary toxicity : Pulmonary infiltrates and/or fibrosis occurs with Gleostine
Advise males and females of reproductive potential of the potential risk to a fetus and to use effective contraception
1 Delayed Myelosuppression Gleostine causes myelosuppression that can result in fatal infections and bleeding
2 Risk of Overdosage Fatal toxicity occurs with overdosage of Gleostine

Known Side Effects

6 documented side effects by frequency

Nausea

>10%

Fatigue

1-10%

Drug Not Working

1-10%

Vomiting

1-10%

Headache

0.1-1%

Constipation

0.1-1%

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Formulations

Dosage Forms

Tablet

Route

Oral