LOXAPINE

Other

Brand names: Loxapine

Oral

Mechanism of Action

Pharmacodynamics Pharmacologically, loxapine is an antipsychotic for which the exact mode of action has not been established. However, changes in the level of excitability of subcortical inhibitory areas have been observed in several animal species in association with such manifestations of tranquilization as calming effects and suppression of aggressive behavior. In normal human volunteers, signs of sedation were seen within 20 to 30 minutes after administration, were most pronounced within one

Indications

INDICATIONS AND USAGE Loxapine Capsules

Contraindications

• CONTRAINDICATIONS Loxapine is contraindicated in comatose or severe drug-induced depressed states (alcohol
• barbiturates
• narcotics
• etc.). Loxapine is contraindicated in individuals with known hypersensitivity to dibenzoxazepines.

FDA Warnings

WARNING Increased Mortality in Elderly Patients with Dementia-Related Psychosis Elderly patients with dementia-related psychosis treated with antipsychotic drugs are at an increased risk of death
Analyses of seventeen placebo-controlled trials (modal duration of 10 weeks), largely in patients taking atypical antipsychotic drugs, revealed a risk of death in drug-treated patients of between 1
7 times the risk of death in placebo-treated patients
Over the course of a typical 10-week controlled trial, the rate of death in drug-treated patients was about 4

Known Side Effects

3 documented side effects by frequency

Drug Not Working

>10%

Drowsiness

1-10%

Weight Gain

1-10%

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Formulations

Dosage Forms

Tablet

Route

Oral