LURASIDONE HYDROCHLORIDE

Atypical Antipsychotic

Brand names: Lurasidone Hydrochloride, Latuda

Oral

Mechanism of Action

12.1 Mechanism of Action The mechanism of action of lurasidone in the treatment of schizophrenia and bipolar depression is unclear. However, its efficacy in schizophrenia and bipolar depression could be mediated through a combination of central dopamine D 2 and serotonin Type 2 (5HT 2A ) receptor antagonism.

Indications

14.1 ) • Depressive episode associated with Bipolar I Disorder (bipolar depression) in adults and pediatric patients (10 to 17 years) as monotherapy ( 1

14.2 ) • Depressive episode associated with Bipolar I Disorder (bipolar depression) in adults as adjunctive therapy with lithium or valproate ( 1

14.2 )

Contraindications

• ketoconazole
• clarithromycin
• ritonavir
• voriconazole
• mibefradil

FDA Warnings

5 WARNINGS AND PRECAUTIONS • Cerebrovascular Adverse Reactions in Elderly Patients with Dementia-Related Psychosis: Increased incidence of cerebrovascular adverse events (e
• Orthostatic Hypotension and Syncope: Monitor heart rate and blood pressure and warn patients with known cardiovascular or cerebrovascular disease, and risk of dehydration or syncope ( 5
1 Increased Mortality in Elderly Patients with Dementia-Related Psychosis Elderly patients with dementia-related psychosis treated with antipsychotic drugs are at an increased risk of death
Analyses of 17 placebo-controlled trials (modal duration of 10 weeks), largely in patients taking atypical antipsychotic drugs, revealed a risk of death in drug-treated patients of between 1

Known Side Effects

10 documented side effects by frequency

Drug Not Working

>10%

Anxiety

1-10%

Depression

1-10%

Weight Gain

1-10%

Drowsiness

1-10%

Nausea

1-10%

Insomnia

1-10%

Fatigue

1-10%

Tremor

0.1-1%

Vomiting

0.1-1%

Community Discussions

1 Reddit threads analysed for LURASIDONE HYDROCHLORIDE

Overall Sentiment

Mixed

Comparison Threads

Avg Post Score

701 upvotes

Patient Experiences (r/pharmacy, r/AskDocs & more)

college is destroying me from the inside out

r/depressionmeals701522y ago

Community discussions are sourced from public Reddit threads. Content reflects individual opinions and is not medical advice.

Compare With

16 available comparisons

Formulations

Dosage Forms

Tablet

Route

Oral