MEMANTINE HYDROCHLORIDE

Alzheimer's Agent

Brand names: Memantine Hydrochloride

Oral

Mechanism of Action

12.1 Mechanism of Action Persistent activation of central nervous system N-methyl-D-aspartate (NMDA) receptors by the excitatory amino acid glutamate has been hypothesized to contribute to the symptomatology of Alzheimer's disease. Memantine is postulated to exert its therapeutic effect through its action as a low to moderate affinity uncompetitive (open-channel) NMDA receptor antagonist which binds preferentially to the NMDA receptor-operated cation channels. There is no evidence that memantine prevents or slows neurodegeneration in patients with Alzheimer's disease.

Indications

USP are indicated for the treatment of moderate to severe dementia of the Alzheimer's type.

FDA Warnings

5 WARNINGS AND PRECAUTIONS Conditions that raise urine pH may decrease the urinary elimination of memantine, resulting in increased plasma levels of memantine

Known Side Effects

10 documented side effects by frequency

Falls

>10%

Drug Not Working

1-10%

Fatigue

1-10%

Condition Worsened

1-10%

Dizziness

1-10%

Weakness

1-10%

Drowsiness

0.1-1%

Nausea

0.1-1%

UTI

0.1-1%

Diarrhea

0.1-1%

Community Discussions

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Compare With

8 available comparisons

Formulations

Dosage Forms

Tablet

Route

Oral