MENTHOL 5%

Other

Brand names: Lidothol ES

Transdermal

Mechanism of Action

Pharmacodynamics Menthol works by targeting the κ-opioid receptor on the TRPM8 neuron. The TRPM8 neuron is normally activated at temperatures between 46.4–82.4 °F (8–28 °C). Menthol causes the neuron to fire at temperatures above normal activation, which triggers the characteristic cooling sensation. Also, because of menthol’s specific targeting of the κ-opioid receptor, it is endowed with analgesic properties. Lidocaine is an amide-type local anesthetic agent and is suggested to stabilize neuro

Indications

simple backache

tendonitis

osteoarthritis

rheumatoid arthritis

peripheral neuropathies such as diabetic neuropathy or post-herpetic neuralgia

and other complex regional pains. It can also be used to help with certain types of headaches

Contraindications

• CONTRAINDICATIONS Lidothol® ES is contraindicated in patients with a known history of sensitivity to local anesthetics of the amide type
• or to any other component of the product.

FDA Warnings

WARNINGS AND PRECAUTIONS Excessive dosage or short intervals between doses can result in high plasma levels and serious adverse effects
The management of serious adverse reactions may require the use of resuscitative equipment, oxygen, or other resuscitative drugs
Although all patients are at risk for methemoglobinemia, patients with glucose-6-phosphate dehydrogenase deficiency, congenital or idiopathic methemoglobinemia, cardiac or pulmonary compromise, infants under 6 months of age, and concurrent exposure to oxidizing agents or their metabolites are more susceptible to developing clinical manifestations of the condition
Methemoglobin levels may continue to rise; therefore, immediate treatment is required to avert more serious central nervous system and cardiovascular adverse effects, including seizures, coma, arrhythmias, and death

Known Side Effects

10 documented side effects by frequency

Drug Not Working

>10%

Fatigue

1-10%

Nausea

1-10%

Headache

1-10%

Shortness of Breath

1-10%

Diarrhea

1-10%

Vomiting

1-10%

Dizziness

0.1-1%

Falls

0.1-1%

Fever

0.1-1%

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Formulations

Dosage Forms

Tablet

Route

Transdermal