What are the most common side effects of Metformin Hydrochloride Extended-Release Tablets?

Reported side effects vary by individual. The side-effects section on this page lists the events most frequently reported to FDA FAERS for Metformin Hydrochloride Extended-Release Tablets. FAERS is voluntary reporting, so it reflects what was reported, not absolute incidence.

Is Metformin Hydrochloride Extended-Release Tablets the same as Metformin Hydrochloride?

Metformin Hydrochloride is a brand name for Metformin Hydrochloride Extended-Release Tablets. They share the same active ingredient and FDA-approved indications. Biosimilars and authorised generics may differ in inactive ingredients such as buffers or preservatives.

Metformin Hydrochloride Extended-Release Tablets

Q: What is Metformin Hydrochloride Extended-Release Tablets used for?

Metformin Hydrochloride Extended-Release Tablets (brand name Metformin Hydrochloride) is a Biguanide indicated for See full prescribing information.

Q: How does Metformin Hydrochloride Extended-Release Tablets work?

Metformin Hydrochloride Extended-Release Tablets works through the following mechanism: Other agent.

Biguanide

Brand names: Metformin Hydrochloride

Oral

Mechanism of Action

Other agent

Indications

See full prescribing information

Contraindications

• including diabetic ketoacidosis
• with or without coma. Severe renal impairment: (eGFR below 30 mL/minute/1.73 m 2 ) ( 4
• 5.1 ) Known hypersensitivity to metformin ( 4 ) Acute or chronic metabolic acidosis
• including diabetic ketoacidosis
• with or without coma ( 4 )

FDA Warnings

5 WARNINGS AND PRECAUTIONS Lactic Acidosis : See boxed warning
2 ) Hypoglycemia with Concomitant Use with Insulin and Insulin Secretagogues : Increased risk of hypoglycemia when used in combination with insulin and/or an insulin secretagogue
1 Lactic Acidosis There have been postmarketing cases of metformin-associated lactic acidosis, including fatal cases
Metformin decreases liver uptake of lactate increasing lactate blood levels which may increase the risk of lactic acidosis, especially in patients at risk

Known Side Effects

10 documented side effects by frequency

Nausea

>10%

Diarrhea

1-10%

Drug Not Working

1-10%

Fatigue

1-10%

Vomiting

1-10%

Weight Loss

1-10%

Shortness of Breath

1-10%

Dizziness

1-10%

Headache

1-10%

Weakness

0.1-1%

Community Discussions

No community discussions found for Metformin Hydrochloride Extended-Release Tablets yet.

Primary sources

Every figure on this page links back to its primary source. See data sources for full provenance.

DailyMed FDA label search → Metformin Hydrochloride Extended-Release Tablets openFDA label JSON → Metformin Hydrochloride Extended-Release Tablets FAERS adverse-event reports → Metformin Hydrochloride Extended-Release Tablets ClinicalTrials.gov → completed Phase 2+ trials of Metformin Hydrochloride Extended-Release Tablets

Compare With

9 available comparisons

Formulations

Dosage Forms

Tablet

Route

Oral