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Brand names: Methadone Hydrochloride
12.1 Mechanism of Action Methadone hydrochloride is a mu-agonist; a synthetic opioid with multiple actions qualitatively similar to those of morphine, the most prominent of which involves the central nervous system and organs composed of smooth muscle. The principal therapeutic uses for methadone are for analgesia and for detoxification or maintenance in opioid addiction. The methadone withdrawal syndrome, although qualitatively similar to that of morphine, differs in that the onset is slower, the course is more prolonged, and the symptoms are less severe. Some data also indicate that methadone acts as an antagonist at the N-methyl-D-aspartate (NMDA) receptor. The contribution of NMDA receptor antagonism to methadone’s efficacy is unknown.
Contraindications
3 documented side effects by frequency
5 Reddit threads analysed for METHADONE
Overall Sentiment
Mixed
Comparison Threads
0
Avg Post Score
118 upvotes
I am an inpatient staffer, and I received these orders today. They were entered on a trauma patient with no correct birthdate or merging chart to get any PMH. Urine tox negative for methadone. Trauma service blindly entered these orders without knowing why patient takes these meds, if patient actual
I am beyond furious and would like some perspective. I was notified by my patient that Walmart would no longer fill Rx from me. So naturally I called that Walmart. (I am a NP in pain management group)... the pharmacist I spoke with was quite rude and blunt, telling me I am a high prescriber and that
So, this is my first post here, and I would really appreciate your opinion comrades- I am a newly registered pharmacist in Canada (March 2020) that started working as a floater as soon as I was registered. After few months of being all over the place, one day I ended up in methadone pharmacy, in whi
I work as an inpatient pharmacist. We have a local PCP who I often find will prescribe meds that are inappropriate for his patients for various reasons (e.g. elderly patient on 3 anticholinergics admitted for what ended up being anticholinergic side effects) or will prescribe high risk meds and no
It's been awhile since I have managed a methadone conversion patient, so I wanted to get some input as well as tips and tricks from those in pain management. Here's the situation: Female, 30's, palliative care cancer patient. She is stage 4 and currently getting palliative radiation. She is using th
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2 available comparisons
Dosage Forms
Tablet
Route
Oral