METHYLENE BLUE

Other

Brand names: Methylene Blue

Intravenous

Mechanism of Action

12.1 Mechanism of Action Methylene blue is a water soluble thiazine dye that promotes a non-enzymatic redox conversion of metHb to hemoglobin. In situ, methylene blue is first converted to leucomethylene blue (LMB) via NADPH reductase. It is the LMB molecule which then reduces the ferric iron of metHb to the ferrous state of normal hemoglobin.

Indications

See full prescribing information

FDA Warnings

5 WARNINGS AND PRECAUTIONS Hypersensitivity: If severe or life threatening allergic reaction occurs, discontinue methylene blue injection, treat the allergic reaction, and monitor until signs and symptoms resolve
Opioids and dextromethorphan may increase the risk of developing serotonin syndrome
Some of the reported cases were fatal
Inform patients of the increased risk of serotonin syndrome and advise them to not to take serotonergic drugs within 72 hours after the last dose of methylene blue injection [see Drug Interactions (7) , Patient Counseling Information (17) ]

Known Side Effects

2 documented side effects by frequency

Drug Not Working

>10%

Low Blood Pressure

1-10%

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Formulations

Dosage Forms

Tablet

Route

Intravenous