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Brand names: Metoprolol Tartrate and Hydrochlorothiazide
12.1 Mechanism of Action Metoprolol is a beta 1 -selective (cardioselective) adrenergic receptor blocker. This preferential effect is not absolute however, and at higher plasma concentrations, metoprolol also inhibits beta2-adrenoreceptors, chiefly located in the bronchial and vascular musculature. Metoprolol has no intrinsic sympathomimetic activity, and membrane-stabilizing activity is detectable only at plasma concentrations much greater than required for beta-blockade. Animal and human experiments indicate that metoprolol slows the sinus rate and decreases AV nodal conduction. The mechanism of the antihypertensive effects of beta-blocking agents has not been elucidated. However, several possible mechanisms have been proposed: (1) competitive antagonism of catecholamines at peripheral (especially cardiac) adrenergic neuron sites, leading to decreased cardiac output; (2) a central effect leading to reduced sympathetic outflow to the periphery; and (3) suppression of renin activity. T
Contraindications
11 documented side effects by frequency
5 Reddit threads analysed for METOPROLOL TARTRATE AND HYDROCHLOROTHIAZIDE
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Mixed
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0
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44 upvotes
Okay, I'll attempt to keep this short. I have a patient who is a chiropractor (86 years old) and he thinks he knows a lot more than he actually does about medicine. He has a doctor (who is 70+ years old) that will write him ANYTHING he wants. 86 year old man has active pulmonary TB, just picked
I have a patient who takes metoprolol tartrate 50 mg BID for tachycardia and blood pressure and we got another script for propranolol 10-20 mg as needed for public speaking. Per the doctor the patient will only take the propranolol a max of 10 days per month and won’t take the metoprolol on the days
I’m a staff pharmacist at a large hospital on Epic. I’m wanting to know what kinds of “low-hanging fruit” interventions other people make. I try to fix as many things as I know how, when I have the time. We already do IV/PO conversions and CrCl monitoring on protocols, so I’m mostly talking about “m
For example with metoprolol, you have tartrate or succinate. Or with docusate it’s sodium. What’s the term for the second word? I’m a nurse and I feel like I should know this but don’t. Thanks
Can anybody find a list of the ~Top 100 prescriptions in the country. ClinCalc has a good one but it lumps all the ingredients together and I'm looking for one that provides values for unique drugs and forms (eg, metoprolol tartrate & succinate or alprazolam IR & alprazolam ER). Thanks.
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14 available comparisons
Dosage Forms
Tablet
Route
Oral