MIDAZOLAM IN SODIUM CHLORIDE

Electrolyte / Mineral

Brand names: Midazolam in Sodium Chloride

Intravenous

Mechanism of Action

12.1 Mechanism of Action Midazolam is a short-acting benzodiazepine central nervous system (CNS) depressant.

Indications

1 INDICATIONS AND USAGE Midazolam in sodium chloride injection is indicated: Continuous intravenous infusion for sedation of intubated and mechanically ventilated adult

pediatric

and neonatal patients as a component of anesthesia or during treatment in a critical care setting. ( 1 )

FDA Warnings

5 WARNINGS AND PRECAUTIONS Cardiorespiratory Adverse Reactions : Serious cardiorespiratory adverse reactions have occurred, sometimes resulting in death or permanent neurologic injury
5 ) Debilitation and Comorbid Considerations : Higher risk adult and pediatric surgical patients, elderly patients and debilitated adult and pediatric patients require lower dosages, whether or not concomitant sedating medications have been administered
6 ) Risk of Intra-Arterial Injection : There have been limited reports of intra- arterial injection of midazolam
Weigh benefits against potential risks when considering elective procedures in children under 3 years old

Known Side Effects

5 documented side effects by frequency

Drug Not Working

>10%

Low Blood Pressure

1-10%

Fever

1-10%

Condition Worsened

0.1-1%

Nausea

0.1-1%

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Formulations

Dosage Forms

Tablet

Route

Intravenous