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Brand names: Gomekli
12.1 Mechanism of Action Mirdametinib is an inhibitor of mitogen-activated protein kinase kinases 1 and 2 (MEK1/2). MEK1/2 proteins are upstream regulators of the extracellular signal-related kinase (ERK) pathway. In vitro, mirdametinib inhibited kinase activity of MEK1 and MEK2 and downstream phosphorylation of ERK. In a mouse model of NF1, oral dosing of mirdametinib inhibited ERK phosphorylation and reduced neurofibroma tumor volume and proliferation.
Contraindications
8 documented side effects by frequency
8 Reddit threads analysed for MIRDAMETINIB
Overall Sentiment
Mixed
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Avg Post Score
10 upvotes
Most discussed side effects in community
Hi! I am an ex-prop shop equity trader. This is a daily watchlist for short-term trading: I might trade all/none of the stocks listed, and even stocks not listed! I am targeting potentially good candidates for short-term trading; I have no opinion on them as investments. The potential of the stock m
Hi everyone, I’m posting here to hopefully connect with others who’ve been through something similar and to understand what to expect going forward. My mom (54F) was diagnosed with glioblastoma in March 2024. We initially thought she had early-onset Alzheimer’s because she was forgetting a lot (it r
Hi! I am an ex-prop shop equity trader. This is a daily watchlist for short-term trading: I might trade all/none of the stocks listed, and even stocks not listed! I am targeting potentially good candidates for short-term trading; I have no opinion on them as investments. The potential of the stock m
Hi! I am an ex-prop shop equity trader. This is a daily watchlist for short-term trading: I might trade all/none of the stocks listed, and even stocks not listed! I am targeting potentially good candidates for short-term trading; I have no opinion on them as investments. The potential of the stock m
Hi! I am an ex-prop shop equity trader. This is a daily watchlist for short-term trading: I might trade all/none of the stocks listed, and even stocks not listed! I am targeting potentially good candidates for short-term trading; I have no opinion on them as investments. The potential of the stock m
Anyone here with experience on KOSELUGO or mirdametinib? what are your experiences with it? did you get shrinkage?
This is a daily watchlist for short-term trading: I might trade all/none of the stocks listed, and even stocks not listed! I am targeting potentially good candidates for short-term trading; I have no opinion on them as investments. The potential of the stock moving today is what makes it interesting
Hello all, I have a question about a specific NF scenario/situation I am facing. For starters I am familiar with NF. I, 22M, have NF1 since birth and have been facing challenges with it (pain in certain areas) as well as optic gleoma on the left side and a bowed tibia on my left side. I have had th
Community discussions are sourced from public Reddit threads. Content reflects individual opinions and is not medical advice.
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Dosage Forms
Tablet
Route
Oral