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Brand names: Montelukast, Singulair
12.1 Mechanism of Action The cysteinyl leukotrienes (LTC 4 , LTD 4 , LTE 4 ) are products of arachidonic acid metabolism and are released from various cells, including mast cells and eosinophils. These eicosanoids bind to cysteinyl leukotriene (CysLT) receptors. The CysLT type-1 (CysLT 1 ) receptor is found in the human airway (including airway smooth muscle cells and airway macrophages) and on other pro-inflammatory cells (including eosinophils and certain myeloid stem cells). CysLTs have been correlated with the pathophysiology of asthma and allergic rhinitis. In asthma, leukotriene-mediated effects include airway edema, smooth muscle contraction, and altered cellular activity associated with the inflammatory process. In allergic rhinitis, CysLTs are released from the nasal mucosa after allergen exposure during both early- and late-phase reactions and are associated with symptoms of allergic rhinitis. Montelukast is an orally active compound that binds with high affinity and selectiv
Contraindications
10 documented side effects by frequency
15 Reddit threads analysed for MONTELUKAST
Overall Sentiment
Mixed
Comparison Threads
0
Avg Post Score
93 upvotes
Most discussed side effects in community
Is that a Singulairity?
16M Caucasian, I weigh around 260 , I’m 5’11. I take cetrizine, nasal spray, and montelukast. I have allergies, anxiety, and OCD. As the title says, saying some words makes my vision go weird. Everything will tilt downward. Until I stop pronouncing the word. Words like B, D, M, U, V, and Z are on
28 year old Male, 170 pounds. I had 3 sleep studies done . 2 at home, 1 in the clinic. 2 showed no apnea. And 1 was minor, like so minor he didn't even wanna give me a cpap but did anyway. I don't know what to do anymore. I wake up 5-8 times a night. Usually I do need to pee. Went to a urologist, go
My husband is a 35 year old, 220 pounds, Caucasian male. When ai met him 7 years ago he was in amazing health. We would go for hikes for 10 miles and he would work out every day. He could eat anything and didn't have a single allergy. He would get exercise induced asthma if he did something really i
Age: 35 Sex: F Height: 5'6 Weight: 230 Duration: 1 and a half to 2 years. Occasionally drink/edible gummy consumption (once or twice a month) Country: USA City/State: Austin, TX Hi everyone! I hope all is well. Posting on behalf of my sick GF. My GF has been chronically ill with flu-like symptoms fo
32F. Currently 38w pregnant. Scheduled c section next Saturday. I’m currently on prednisone, Wellbutrin, valacyclovir, Focalin, and albuterol for my asthma + montelukast when it gets really bad during the winter. For context, I’ve had asthma since I was a kid. It’s landed me in the hospital plenty
34 White male, 5'10", 195, symptoms experienced since Memorial Day 2013, skin, lungs, chest, Ranitidine, Doxepin, Nexium, Montelukast, Xolair I was going to a dermatologist for plantars warts on my feet. He was freezing them off. After 3 years with moderate success, he asked me if I wanted to try hi
20 AFAB, My adoptive parents have always told me about how crazy bringing me home from the hosptial was because they didnt think i was going to be able to leave for at least 4 weeks initially. I was born 6 weeks early. The reasoning that my parents have always told me (as well as many other relativ
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11 available comparisons
Dosage Forms
Tablet
Route
Oral